Interactions between Bisphenol A exposure and GSTP1 polymorphisms in childhood asthma

Tien-Jen Lin, Wilfried J.J. Karmaus, Mei Lien Chen, Jiin Chyr Hsu, I. Jen Wang

Research output: Contribution to journalArticle

Abstract

Purpose: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione Stransferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. Methods: We conducted a case-control study comprised of 126 asthmatic children and 327 controls. Urine Bisphenol A glucuronide (BPAG) levels were measured by ultra-performance liquid chromatography/tandem mass spectrometry, and genetic variants were analyzed by a TaqMan assay. Information on asthma and environmental exposure was collected. Analyses of variance and logistic regressions were performed to determine the association of genotypes and urine BPAG levels with asthma. Results: BPAG levels were significantly associated with asthma (adjusted odds ratio [aOR], 1.29 per log unit increase in concentration; 95% confidence interval [CI], 1.081.55). Compared to the GG genotype, children with a GSTP1 AA genotype had higher urine BPAG concentrations (geometric mean [standard error], 12.72 [4.16] vs 11.42 [2.82]; P=0.036). In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06). Conclusions: GSTP1 variants are associated with urine BPA metabolite levels. Oxidative stress genes may modulate the effect of BPA exposure on asthma.

Original languageEnglish
Pages (from-to)172-179
Number of pages8
JournalAllergy, Asthma and Immunology Research
Volume10
Issue number2
DOIs
Publication statusPublished - Mar 1 2018

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Asthma
Genotype
Urine
Oxidative Stress
Odds Ratio
Confidence Intervals
Genes
Epoxide Hydrolases
Environmental Exposure
Genetic Polymorphisms
Tandem Mass Spectrometry
bisphenol A
Liquid Chromatography
Catalase
Peroxidase
Superoxide Dismutase
Glutathione
Case-Control Studies
Analysis of Variance
Logistic Models

Keywords

  • Asthma
  • Bisphenol A
  • Genotype
  • GSTP1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Interactions between Bisphenol A exposure and GSTP1 polymorphisms in childhood asthma. / Lin, Tien-Jen; Karmaus, Wilfried J.J.; Chen, Mei Lien; Hsu, Jiin Chyr; Wang, I. Jen.

In: Allergy, Asthma and Immunology Research, Vol. 10, No. 2, 01.03.2018, p. 172-179.

Research output: Contribution to journalArticle

Lin, Tien-Jen ; Karmaus, Wilfried J.J. ; Chen, Mei Lien ; Hsu, Jiin Chyr ; Wang, I. Jen. / Interactions between Bisphenol A exposure and GSTP1 polymorphisms in childhood asthma. In: Allergy, Asthma and Immunology Research. 2018 ; Vol. 10, No. 2. pp. 172-179.
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abstract = "Purpose: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione Stransferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. Methods: We conducted a case-control study comprised of 126 asthmatic children and 327 controls. Urine Bisphenol A glucuronide (BPAG) levels were measured by ultra-performance liquid chromatography/tandem mass spectrometry, and genetic variants were analyzed by a TaqMan assay. Information on asthma and environmental exposure was collected. Analyses of variance and logistic regressions were performed to determine the association of genotypes and urine BPAG levels with asthma. Results: BPAG levels were significantly associated with asthma (adjusted odds ratio [aOR], 1.29 per log unit increase in concentration; 95{\%} confidence interval [CI], 1.081.55). Compared to the GG genotype, children with a GSTP1 AA genotype had higher urine BPAG concentrations (geometric mean [standard error], 12.72 [4.16] vs 11.42 [2.82]; P=0.036). In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95{\%} CI, 1.0223.06). Conclusions: GSTP1 variants are associated with urine BPA metabolite levels. Oxidative stress genes may modulate the effect of BPA exposure on asthma.",
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