Integrated human papillomavirus types 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancer

Chih Ming Ho, Tsai Yen Chien, Shih Hung Huang, Bor Heng Lee, Shwu Fen Chang

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Objective.: The aim of this prospective study was to analyze whether integration or high viral loads of human papillomavirus (HPV) is essential for malignant transformation of HPV types 52 and 58 as well as types 16 and 18. Methods.: Cervical swabs from 178 consecutive patients, including 81 with invasive cervical cancers and 97 with cervical intraepithelial neoplasias (CIN) II-III, were collected and examined to determine the physical status and viral load of HPV types 16, 18, 52 and 58 DNA using genechip and real-time PCR (polymerase chain reaction) analysis. Results.: In cervical cancer patients, the integrated form of HPV 52 and 58 DNA was found in 25.0% and 12.5% of swabs, respectively; while HPV16 and 18 DNA was found in 82.6% and 100% of swabs, respectively (P 

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalGynecologic Oncology
Volume102
Issue number1
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Cervical intraepithelial neoplasia
  • HPV
  • Integration
  • Polymerase chain reaction
  • Viral load

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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