Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability

Po Hsun Huang, Yung Hsiang Chen, Hsiao Ya Tsai, Jia Shiong Chen, Tao Cheng Wu, Feng Yen Lin, Masataka Sata, Jaw Wen Chen, Shing Jong Lin

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105 Citations (Scopus)


Objective: Red wine (RW) consumption has been associated with a reduction of cardiovascular events, but limited data are available on potential mediating mechanisms. This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability. Methods and results: Eighty healthy, young subjects were randomized and assigned to consume water (100 mL), RW (100 mL), beer (250 mL), or vodka (30 mL) daily for 3 weeks. Flow cytometry was used to quantify circulating EPC numbers, and in vitro assays were used to evaluate EPC functions. After RW ingestion, endothelial function determined by flow-mediated vasodilation was significantly enhanced; however, it remained unchanged after water, beer, or vodka intake. There were significantly increased numbers of circulating EPC (defined as KDR+CD133+, CD34+CD133+, CD34+KDR+) and EPC colony-forming units only in the RW group (all P

Original languageEnglish
Pages (from-to)869-877
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number4
Publication statusPublished - Apr 2010



  • Endothelial function endothelial progenitor cell
  • Nitric oxide
  • Red wine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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