Insulin secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)

Chiung Huei Peng, Yaw Bee Ker, Ching Feng Weng, Chiuno Chi Peng, Chien Ning Huang, L. I Yun Lin, Robert Y. Peng

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), y-terpenene (33.71), α-pinene (3.40), and, β-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-DawleySPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.

Original languageEnglish
Pages (from-to)8812-8819
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number19
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Citrus fruits
Rutaceae
Citrus medica
Citrus
Bioactivity
Fingers
Fruit
insulin
Fruits
Hypoglycemic Agents
Insulin
fruits
hypoglycemic agents
Rats
insulin secretion
rats
glucose tolerance
noninsulin-dependent diabetes mellitus
Glucose
Taiwan

Keywords

  • Antiobese
  • Finger citron fruits
  • Insulin secretagogue
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Insulin secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae). / Peng, Chiung Huei; Ker, Yaw Bee; Weng, Ching Feng; Peng, Chiuno Chi; Huang, Chien Ning; Lin, L. I Yun; Peng, Robert Y.

In: Journal of Agricultural and Food Chemistry, Vol. 57, No. 19, 2009, p. 8812-8819.

Research output: Contribution to journalArticle

Peng, Chiung Huei ; Ker, Yaw Bee ; Weng, Ching Feng ; Peng, Chiuno Chi ; Huang, Chien Ning ; Lin, L. I Yun ; Peng, Robert Y. / Insulin secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae). In: Journal of Agricultural and Food Chemistry. 2009 ; Vol. 57, No. 19. pp. 8812-8819.
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