Abstract

Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.

Original languageEnglish
Article number1541593
JournalBioMed Research International
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

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Multicenter Studies
Renal Dialysis
Insulin Resistance
Insulin
Cardiovascular Diseases
Weights and Measures
Hypoalbuminemia
Hyperhomocysteinemia
Dialysis
Blood pressure
Medical problems
Regression analysis
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Logistics
Fasting
Triglycerides
Multivariate Analysis
Cross-Sectional Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients : A Multicenter Study. / Duong, Tuyen Van; Shih, Chun Kuang; Wong, Te Chih; Chen, Hsi Hsien; Chen, Tso Hsiao; Hsu, Yung Ho; Peng, Sheng Jeng; Kuo, Ko Lin; Liu, Hsiang Chung; Lin, En Tzu; Su, Chien Tien; Yang, Shwu Huey.

In: BioMed Research International, Vol. 2019, 1541593, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients: A Multicenter Study",
abstract = "Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1{\%} men, and 40.3{\%} overweight/obese. The median of HOMA-IR was 5.4, 82.8{\%} high systolic blood pressure, and 85.7{\%} hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95{\%} confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95{\%} CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95{\%} CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.",
author = "Duong, {Tuyen Van} and Shih, {Chun Kuang} and Wong, {Te Chih} and Chen, {Hsi Hsien} and Chen, {Tso Hsiao} and Hsu, {Yung Ho} and Peng, {Sheng Jeng} and Kuo, {Ko Lin} and Liu, {Hsiang Chung} and Lin, {En Tzu} and Su, {Chien Tien} and Yang, {Shwu Huey}",
year = "2019",
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T1 - Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients

T2 - A Multicenter Study

AU - Duong, Tuyen Van

AU - Shih, Chun Kuang

AU - Wong, Te Chih

AU - Chen, Hsi Hsien

AU - Chen, Tso Hsiao

AU - Hsu, Yung Ho

AU - Peng, Sheng Jeng

AU - Kuo, Ko Lin

AU - Liu, Hsiang Chung

AU - Lin, En Tzu

AU - Su, Chien Tien

AU - Yang, Shwu Huey

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.

AB - Background. To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients. Methods. We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used. Results. Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p <.05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p <.01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p <.01), and overall sample (OR=3.07, 1.51-6.23, p <.01). Conclusions. The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.

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U2 - 10.1155/2019/1541593

DO - 10.1155/2019/1541593

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VL - 2019

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

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