Abstract
Background & objectives: Lowering the diagnostic threshold of normal fasting plasma glucose (FPG) from 6.1 to 5.56 mmol/l has been proposed by American Diabetes Association. As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels of FPG to investigate the relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-off improves the sensitivity of impaired fasting glucose to predict diabetes. Methods: Apparently healthy subjects (294) were enrolled and divided into 3 groups according to their FPG levels; group 1 (
| Original language | English |
|---|---|
| Pages (from-to) | 527-534 |
| Number of pages | 8 |
| Journal | Indian Journal of Medical Research |
| Volume | 124 |
| Publication status | Published - Nov 2006 |
| Externally published | Yes |
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Keywords
- Fasting plasma glucose
- Insulin resistance
- Insulin secretion
- Insulin suppression test
- Insulinogenic index
- Metabolic syndrome
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Insulin resistance & secretion in subjects with normal fasting plasma glucose. / Hsieh, Chang Hsun; Hung, Yi Jen; Wu, Chung Ze; Lee, Shang Sen; Lee, Chien Hsing; Chen, Cheng Yu; Li, Jur Chuan; Kuo, Shi Wen; Kuo, Ko Lin; Pei, Dee.
In: Indian Journal of Medical Research, Vol. 124, 11.2006, p. 527-534.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin resistance & secretion in subjects with normal fasting plasma glucose
AU - Hsieh, Chang Hsun
AU - Hung, Yi Jen
AU - Wu, Chung Ze
AU - Lee, Shang Sen
AU - Lee, Chien Hsing
AU - Chen, Cheng Yu
AU - Li, Jur Chuan
AU - Kuo, Shi Wen
AU - Kuo, Ko Lin
AU - Pei, Dee
PY - 2006/11
Y1 - 2006/11
N2 - Background & objectives: Lowering the diagnostic threshold of normal fasting plasma glucose (FPG) from 6.1 to 5.56 mmol/l has been proposed by American Diabetes Association. As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels of FPG to investigate the relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-off improves the sensitivity of impaired fasting glucose to predict diabetes. Methods: Apparently healthy subjects (294) were enrolled and divided into 3 groups according to their FPG levels; group 1 (
AB - Background & objectives: Lowering the diagnostic threshold of normal fasting plasma glucose (FPG) from 6.1 to 5.56 mmol/l has been proposed by American Diabetes Association. As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels of FPG to investigate the relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-off improves the sensitivity of impaired fasting glucose to predict diabetes. Methods: Apparently healthy subjects (294) were enrolled and divided into 3 groups according to their FPG levels; group 1 (
KW - Fasting plasma glucose
KW - Insulin resistance
KW - Insulin secretion
KW - Insulin suppression test
KW - Insulinogenic index
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=33846513379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846513379&partnerID=8YFLogxK
M3 - Article
VL - 124
SP - 527
EP - 534
JO - Indian Journal of Medical Research
JF - Indian Journal of Medical Research
SN - 0971-5916
ER -