Insulin resistance & secretion in subjects with normal fasting plasma glucose

Chang Hsun Hsieh; Yi Jen Hung; Chung Ze Wu; Shang Sen Lee; Chien Hsing Lee; Cheng Yu Chen; Jur Chuan Li; Shi Wen Kuo; Ko Lin Kuo; Dee Pei

Insulin resistance & secretion in subjects with normal fasting plasma glucose

Chang Hsun Hsieh, Yi Jen Hung, Chung Ze Wu, Shang Sen Lee, Chien Hsing Lee, Cheng Yu Chen, Jur Chuan Li, Shi Wen Kuo, Ko Lin Kuo, Dee Pei

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background & objectives: Lowering the diagnostic threshold of normal fasting plasma glucose (FPG) from 6.1 to 5.56 mmol/l has been proposed by American Diabetes Association. As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels of FPG to investigate the relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-off improves the sensitivity of impaired fasting glucose to predict diabetes. Methods: Apparently healthy subjects (294) were enrolled and divided into 3 groups according to their FPG levels; group 1 (

Original language	English
Pages (from-to)	527-534
Number of pages	8
Journal	Indian Journal of Medical Research
Volume	124
Publication status	Published - Nov 2006
Externally published	Yes

Keywords

Fasting plasma glucose
Insulin resistance
Insulin secretion
Insulin suppression test
Insulinogenic index
Metabolic syndrome

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Background & objectives: Lowering the diagnostic threshold of normal fasting plasma glucose (FPG) from 6.1 to 5.56 mmol/l has been proposed by American Diabetes Association. As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels of FPG to investigate the relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-off improves the sensitivity of impaired fasting glucose to predict diabetes. Methods: Apparently healthy subjects (294) were enrolled and divided into 3 groups according to their FPG levels; group 1 (",

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author = "Hsieh, {Chang Hsun} and Hung, {Yi Jen} and Wu, {Chung Ze} and Lee, {Shang Sen} and Lee, {Chien Hsing} and Chen, {Cheng Yu} and Li, {Jur Chuan} and Kuo, {Shi Wen} and Kuo, {Ko Lin} and Dee Pei",

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T1 - Insulin resistance & secretion in subjects with normal fasting plasma glucose

AU - Hsieh, Chang Hsun

AU - Hung, Yi Jen

AU - Wu, Chung Ze

AU - Lee, Shang Sen

AU - Lee, Chien Hsing

AU - Chen, Cheng Yu

AU - Li, Jur Chuan

AU - Kuo, Shi Wen

AU - Kuo, Ko Lin

AU - Pei, Dee

PY - 2006/11

Y1 - 2006/11

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KW - Fasting plasma glucose

KW - Insulin resistance

KW - Insulin secretion

KW - Insulin suppression test

KW - Insulinogenic index

KW - Metabolic syndrome

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