Insulin resistance & secretion in subjects with normal fasting plasma glucose

Chang Hsun Hsieh, Yi Jen Hung, Chung Ze Wu, Shang Sen Lee, Chien Hsing Lee, Cheng Yu Chen, Jur Chuan Li, Shi Wen Kuo, Ko Lin Kuo, Dee Pei

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background & objectives: Lowering the diagnostic threshold of normal fasting plasma glucose (FPG) from 6.1 to 5.56 mmol/l has been proposed by American Diabetes Association. As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels of FPG to investigate the relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-off improves the sensitivity of impaired fasting glucose to predict diabetes. Methods: Apparently healthy subjects (294) were enrolled and divided into 3 groups according to their FPG levels; group 1 (

Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalIndian Journal of Medical Research
Volume124
Publication statusPublished - Nov 2006
Externally publishedYes

Keywords

  • Fasting plasma glucose
  • Insulin resistance
  • Insulin secretion
  • Insulin suppression test
  • Insulinogenic index
  • Metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Hsieh, C. H., Hung, Y. J., Wu, C. Z., Lee, S. S., Lee, C. H., Chen, C. Y., Li, J. C., Kuo, S. W., Kuo, K. L., & Pei, D. (2006). Insulin resistance & secretion in subjects with normal fasting plasma glucose. Indian Journal of Medical Research, 124, 527-534.