Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan - The Taipei Children Heart Study

An-Tsz Hsieh, Nain Feng Chu, Mu Han Shen, Der Min Wu, Dan Jiang Wang, Shih Ming Hsieh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Evidence suggests that there may be a metabolic syndrome characterized by hyperinsulinemia or insulin resistance associated with increased cardiovascular disease risk. The purpose of this study is to evaluate insulin, proinsulin or insulin resistance to determine which is the best parameter to predict lipid profiles among children in Taiwan. Methods: After multi-stage sampling, we randomly included 852 school children (415 boys and 437 girls) with a mean age of 13 yr in this study. We measured insulin and intact proinsulin levels by RIA (<0.2% cross-reactivity) and estimated insulin resistance index (IRI) using the homeostatic model assessment (HOMA) method. We used standard methods to measure atherosclerotic lipid profiles including total cholesterol (CHOL), triglyceride (TG), HDL-C, apolipoprotein A (ApoA), apolipoprotein B (ApoB), and lipoprotein[a] and calculated LDL-C and TCHR (total cholesterol to HDL-C ratio) levels. Results: Girls had higher CHOL, LDL-C, ApoA and ApoB levels than boys (p < 0.001). There was no significant difference in insulin, proinsulin and IRI status between boys and girls. Among boys, insulin, proinsulin and IRI were positively correlated with TG, ApoB and TCHR and negatively related to HDL-C. Among girls, these associations were attenuated and became insignificantly for TCHR and HDL-C. After adjusting for potential confounders, IRI and insulin were still positively associated with TG and ApoB levels and negatively associated with HDL-C in boys. However, in girls, proinsulin and insulin were positively associated with TG only. Finally, in the stepwise regression analyses, IRI was a better predictor of TG, HDL-C, and ApoB than insulin or proinsulin in boys. However, in girls, proinsulin was a stronger predictor than insulin or IRI for TG and TCHR. Conclusion: From this study, we found that IRI (in boys) and proinsulin (in girls) levels are generally more significant and stronger parameters than insulin for predicting lipid profiles among children in Taiwan.

Original languageEnglish
Pages (from-to)367-372
Number of pages6
JournalClinical Biochemistry
Volume36
Issue number5
DOIs
Publication statusPublished - Jan 1 2003
Externally publishedYes

Fingerprint

Proinsulin
Taiwan
Insulin Resistance
Insulin
Lipids
Apolipoproteins B
Triglycerides
HDL Cholesterol
Apolipoproteins A
Cholesterol
Hyperinsulinism
LDL Cholesterol
Lipoproteins
Cardiovascular Diseases
Regression Analysis

Keywords

  • Insulin
  • Insulin Resistance
  • Lipids profiles
  • Proinsulin

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan - The Taipei Children Heart Study. / Hsieh, An-Tsz; Chu, Nain Feng; Shen, Mu Han; Wu, Der Min; Wang, Dan Jiang; Hsieh, Shih Ming.

In: Clinical Biochemistry, Vol. 36, No. 5, 01.01.2003, p. 367-372.

Research output: Contribution to journalArticle

Hsieh, An-Tsz ; Chu, Nain Feng ; Shen, Mu Han ; Wu, Der Min ; Wang, Dan Jiang ; Hsieh, Shih Ming. / Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan - The Taipei Children Heart Study. In: Clinical Biochemistry. 2003 ; Vol. 36, No. 5. pp. 367-372.
@article{9556d2aa329f42a9b1eea2d911fb5aba,
title = "Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan - The Taipei Children Heart Study",
abstract = "Purpose: Evidence suggests that there may be a metabolic syndrome characterized by hyperinsulinemia or insulin resistance associated with increased cardiovascular disease risk. The purpose of this study is to evaluate insulin, proinsulin or insulin resistance to determine which is the best parameter to predict lipid profiles among children in Taiwan. Methods: After multi-stage sampling, we randomly included 852 school children (415 boys and 437 girls) with a mean age of 13 yr in this study. We measured insulin and intact proinsulin levels by RIA (<0.2{\%} cross-reactivity) and estimated insulin resistance index (IRI) using the homeostatic model assessment (HOMA) method. We used standard methods to measure atherosclerotic lipid profiles including total cholesterol (CHOL), triglyceride (TG), HDL-C, apolipoprotein A (ApoA), apolipoprotein B (ApoB), and lipoprotein[a] and calculated LDL-C and TCHR (total cholesterol to HDL-C ratio) levels. Results: Girls had higher CHOL, LDL-C, ApoA and ApoB levels than boys (p < 0.001). There was no significant difference in insulin, proinsulin and IRI status between boys and girls. Among boys, insulin, proinsulin and IRI were positively correlated with TG, ApoB and TCHR and negatively related to HDL-C. Among girls, these associations were attenuated and became insignificantly for TCHR and HDL-C. After adjusting for potential confounders, IRI and insulin were still positively associated with TG and ApoB levels and negatively associated with HDL-C in boys. However, in girls, proinsulin and insulin were positively associated with TG only. Finally, in the stepwise regression analyses, IRI was a better predictor of TG, HDL-C, and ApoB than insulin or proinsulin in boys. However, in girls, proinsulin was a stronger predictor than insulin or IRI for TG and TCHR. Conclusion: From this study, we found that IRI (in boys) and proinsulin (in girls) levels are generally more significant and stronger parameters than insulin for predicting lipid profiles among children in Taiwan.",
keywords = "Insulin, Insulin Resistance, Lipids profiles, Proinsulin",
author = "An-Tsz Hsieh and Chu, {Nain Feng} and Shen, {Mu Han} and Wu, {Der Min} and Wang, {Dan Jiang} and Hsieh, {Shih Ming}",
year = "2003",
month = "1",
day = "1",
doi = "10.1016/S0009-9120(03)00040-7",
language = "English",
volume = "36",
pages = "367--372",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan - The Taipei Children Heart Study

AU - Hsieh, An-Tsz

AU - Chu, Nain Feng

AU - Shen, Mu Han

AU - Wu, Der Min

AU - Wang, Dan Jiang

AU - Hsieh, Shih Ming

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Purpose: Evidence suggests that there may be a metabolic syndrome characterized by hyperinsulinemia or insulin resistance associated with increased cardiovascular disease risk. The purpose of this study is to evaluate insulin, proinsulin or insulin resistance to determine which is the best parameter to predict lipid profiles among children in Taiwan. Methods: After multi-stage sampling, we randomly included 852 school children (415 boys and 437 girls) with a mean age of 13 yr in this study. We measured insulin and intact proinsulin levels by RIA (<0.2% cross-reactivity) and estimated insulin resistance index (IRI) using the homeostatic model assessment (HOMA) method. We used standard methods to measure atherosclerotic lipid profiles including total cholesterol (CHOL), triglyceride (TG), HDL-C, apolipoprotein A (ApoA), apolipoprotein B (ApoB), and lipoprotein[a] and calculated LDL-C and TCHR (total cholesterol to HDL-C ratio) levels. Results: Girls had higher CHOL, LDL-C, ApoA and ApoB levels than boys (p < 0.001). There was no significant difference in insulin, proinsulin and IRI status between boys and girls. Among boys, insulin, proinsulin and IRI were positively correlated with TG, ApoB and TCHR and negatively related to HDL-C. Among girls, these associations were attenuated and became insignificantly for TCHR and HDL-C. After adjusting for potential confounders, IRI and insulin were still positively associated with TG and ApoB levels and negatively associated with HDL-C in boys. However, in girls, proinsulin and insulin were positively associated with TG only. Finally, in the stepwise regression analyses, IRI was a better predictor of TG, HDL-C, and ApoB than insulin or proinsulin in boys. However, in girls, proinsulin was a stronger predictor than insulin or IRI for TG and TCHR. Conclusion: From this study, we found that IRI (in boys) and proinsulin (in girls) levels are generally more significant and stronger parameters than insulin for predicting lipid profiles among children in Taiwan.

AB - Purpose: Evidence suggests that there may be a metabolic syndrome characterized by hyperinsulinemia or insulin resistance associated with increased cardiovascular disease risk. The purpose of this study is to evaluate insulin, proinsulin or insulin resistance to determine which is the best parameter to predict lipid profiles among children in Taiwan. Methods: After multi-stage sampling, we randomly included 852 school children (415 boys and 437 girls) with a mean age of 13 yr in this study. We measured insulin and intact proinsulin levels by RIA (<0.2% cross-reactivity) and estimated insulin resistance index (IRI) using the homeostatic model assessment (HOMA) method. We used standard methods to measure atherosclerotic lipid profiles including total cholesterol (CHOL), triglyceride (TG), HDL-C, apolipoprotein A (ApoA), apolipoprotein B (ApoB), and lipoprotein[a] and calculated LDL-C and TCHR (total cholesterol to HDL-C ratio) levels. Results: Girls had higher CHOL, LDL-C, ApoA and ApoB levels than boys (p < 0.001). There was no significant difference in insulin, proinsulin and IRI status between boys and girls. Among boys, insulin, proinsulin and IRI were positively correlated with TG, ApoB and TCHR and negatively related to HDL-C. Among girls, these associations were attenuated and became insignificantly for TCHR and HDL-C. After adjusting for potential confounders, IRI and insulin were still positively associated with TG and ApoB levels and negatively associated with HDL-C in boys. However, in girls, proinsulin and insulin were positively associated with TG only. Finally, in the stepwise regression analyses, IRI was a better predictor of TG, HDL-C, and ApoB than insulin or proinsulin in boys. However, in girls, proinsulin was a stronger predictor than insulin or IRI for TG and TCHR. Conclusion: From this study, we found that IRI (in boys) and proinsulin (in girls) levels are generally more significant and stronger parameters than insulin for predicting lipid profiles among children in Taiwan.

KW - Insulin

KW - Insulin Resistance

KW - Lipids profiles

KW - Proinsulin

UR - http://www.scopus.com/inward/record.url?scp=0037756680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037756680&partnerID=8YFLogxK

U2 - 10.1016/S0009-9120(03)00040-7

DO - 10.1016/S0009-9120(03)00040-7

M3 - Article

VL - 36

SP - 367

EP - 372

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

IS - 5

ER -