Abstract
Treatment of quiescent Balb c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts.
| Original language | English |
|---|---|
| Pages (from-to) | 524-531 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 183 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 16 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology