Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balb c 3T3 cells

Shean Tai Chiou, Wen Chang Chang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Treatment of quiescent Balb c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts.

Original languageEnglish
Pages (from-to)524-531
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume183
Issue number2
DOIs
Publication statusPublished - Mar 16 1992
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this