Insulin-like growth factor-binding protein-3 in breast cancer: analysis with tissue microarray

Shyr Ming Sheen-Chen, Hao Zhang, Chao Cheng Huang, Rei Ping Tang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: IGFBP-3 has been reported to be growth-stimulatory. The creation of tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed with the application of TMA to analyze the IGFBP-3 status in breast cancer with the hope to elucidate the possible relationship between IGFBP-3 expression and breast cancer biology. Materials and Methods: Archival tissue specimens from 97 patients with primary invasive breast cancer were selected. The IGFBP-3 expression was analyzed by TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected. Results: There were 40 patients (41%) with 0-1 expression of IGFBP-3, 52 patients (54%) with 2 expression of IGFBP-3 and 5 patients (5%) with 3 expression in IGFBP-3. By multivariate analysis, the IGFBP-3 expression turned out to be significantly related to the overall five-year survival rate. Conclusion: The preliminary results about IGFBP-3 expression in breast cancer are intriguing and require further evaluation.

Original languageEnglish
Pages (from-to)1131-1136
Number of pages6
JournalAnticancer Research
Volume29
Issue number4
Publication statusPublished - Apr 1 2009
Externally publishedYes

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Tissue Array Analysis
Insulin-Like Growth Factor Binding Protein 3
Breast Neoplasms
Neoplasm Staging
Insulin-Like Growth Factor Binding Protein 5
Estrogen Receptors
Multivariate Analysis
Survival Rate
Lymph Nodes

Keywords

  • Breast cancer
  • IGFBP-3
  • Tissue microarray

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Insulin-like growth factor-binding protein-3 in breast cancer : analysis with tissue microarray. / Sheen-Chen, Shyr Ming; Zhang, Hao; Huang, Chao Cheng; Tang, Rei Ping.

In: Anticancer Research, Vol. 29, No. 4, 01.04.2009, p. 1131-1136.

Research output: Contribution to journalArticle

Sheen-Chen, Shyr Ming ; Zhang, Hao ; Huang, Chao Cheng ; Tang, Rei Ping. / Insulin-like growth factor-binding protein-3 in breast cancer : analysis with tissue microarray. In: Anticancer Research. 2009 ; Vol. 29, No. 4. pp. 1131-1136.
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