Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma

P. L. Torng, Y. C G Lee, C. Y F Huang, J. H. Ye, Y. S. Lin, Y. W. Chu, S. C. Huang, P. Cohen, C. W. Wu, C. T. Lin

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54 Citations (Scopus)

Abstract

Metastasis and invasion occur in the majority of epithelial ovarian carcinoma at diagnosis. To delineate the molecular signature in ovarian cancer invasion, we established and characterized a human ovarian endometrioid carcinoma (EC) cell line OVTW59-P0 and its invasion-related sublines (P1-P4, in the order of increasing invasive activity). P4 showed faster migration and larger xenograft formation with metastasis than P0. By microarray analysis of different gene expression among P0-P4 sublines, one group of gene was found negatively correlated with cancer invasion. Among these genes, IGFBP-3 was identified as one of the most remarkably suppressed gene that showed lower gene expression in P4 than P0. Re-expression of IGFBP-3 in P4 effectively inhibited cell migration, invasion and metastasis, but did not affect cell proliferation. In 35 patients with EC tumors, low IGFBP-3 expression correlated clinically with higher tumor grade, advanced stage and poor survival. Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC.

Original languageEnglish
Pages (from-to)2137-2147
Number of pages11
JournalOncogene
Volume27
Issue number15
DOIs
Publication statusPublished - Apr 3 2008

Keywords

  • Insulin-like growth factor binding protein-3
  • Invasion
  • Ovarian endometrioid carcinoma
  • Suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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    Torng, P. L., Lee, Y. C. G., Huang, C. Y. F., Ye, J. H., Lin, Y. S., Chu, Y. W., Huang, S. C., Cohen, P., Wu, C. W., & Lin, C. T. (2008). Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. Oncogene, 27(15), 2137-2147. https://doi.org/10.1038/sj.onc.1210864