Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu, Hung Tsung Wu, Yi Hsuan Hsiao, Chih Wei Lai, Chun Wei Shih, Yung Kang Peng, Kuo Chun Tang, Hsing Wei Chang, Yun Chen Chien, Jong Kai Hsiao, Juei Tang Cheng, Pi Tai Chou

Research output: Contribution to journalArticle

290 Citations (Scopus)

Abstract

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

Original languageEnglish
Pages (from-to)7056-7060
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number31
DOIs
Publication statusPublished - Jul 25 2011
Externally publishedYes

Fingerprint

Nanoclusters
Insulin
Bioactivity
Gold
Imaging techniques
Insulysin
Fluorescence
Biocompatibility
Tomography
Blood Glucose
Glucose
X rays
Blood
Enzymes

Keywords

  • biomaterials
  • fluorescence
  • gold
  • imaging agents
  • nanostructures

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Insulin-directed synthesis of fluorescent gold nanoclusters : Preservation of insulin bioactivity and versatility in cell imaging. / Liu, Chien Liang; Wu, Hung Tsung; Hsiao, Yi Hsuan; Lai, Chih Wei; Shih, Chun Wei; Peng, Yung Kang; Tang, Kuo Chun; Chang, Hsing Wei; Chien, Yun Chen; Hsiao, Jong Kai; Cheng, Juei Tang; Chou, Pi Tai.

In: Angewandte Chemie - International Edition, Vol. 50, No. 31, 25.07.2011, p. 7056-7060.

Research output: Contribution to journalArticle

Liu, CL, Wu, HT, Hsiao, YH, Lai, CW, Shih, CW, Peng, YK, Tang, KC, Chang, HW, Chien, YC, Hsiao, JK, Cheng, JT & Chou, PT 2011, 'Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging', Angewandte Chemie - International Edition, vol. 50, no. 31, pp. 7056-7060. https://doi.org/10.1002/anie.201100299
Liu, Chien Liang ; Wu, Hung Tsung ; Hsiao, Yi Hsuan ; Lai, Chih Wei ; Shih, Chun Wei ; Peng, Yung Kang ; Tang, Kuo Chun ; Chang, Hsing Wei ; Chien, Yun Chen ; Hsiao, Jong Kai ; Cheng, Juei Tang ; Chou, Pi Tai. / Insulin-directed synthesis of fluorescent gold nanoclusters : Preservation of insulin bioactivity and versatility in cell imaging. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 31. pp. 7056-7060.
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