Instability of spontaneous breathing patterns in patients with persistent vegetative state

Mauo Ying Bien, Huey Wen Yien, Shu Shya Hseu, Jia Horng Wang, Yu Ru Kou

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers. During the baseline period breathing air, 15 patients (the PVS-IB) exhibited irregular breathing (IB), whereas the other 12 (the PVS-OB) displayed oscillatory breathing (OB). Both groups maintained an average value for tidal volume (VT), total breath duration (TTOT), minute ventilation (V̇E), oxygen saturation (SpO2) similar to the control, but the PVS-OB displayed significantly lower end-tidal CO2 tension (P ETCO2) than the control. The VT, T TOT, V̇E and PETCO2 of the PVS-OB showed cyclic changes. The coefficients of variation of VT, TTOT and V̇I were: PVS-OB > PVS-IB > control. Inhalation of 100% O2 significantly reduced the respiratory variability and prevented OB of the PVS-OB. We concluded that PVS patients display respiratory instability and that brain damage, hypocapnia, and/or increased loop gain of arterial chemoreceptors may contribute to the pathogenesis of OB, whereas brain damage presumably may be the cause of IB.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalRespiratory Physiology and Neurobiology
Volume145
Issue number2-3
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Persistent Vegetative State
Respiration
Ventilation
Hypocapnia
Tidal Volume
Brain

Keywords

  • Brain damage
  • Control of breathing
  • Irregular breathing
  • Oscillatory breathing
  • Peripheral chemoreceptors
  • Respiratory plasticity

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Instability of spontaneous breathing patterns in patients with persistent vegetative state. / Bien, Mauo Ying; Yien, Huey Wen; Hseu, Shu Shya; Wang, Jia Horng; Kou, Yu Ru.

In: Respiratory Physiology and Neurobiology, Vol. 145, No. 2-3, 02.2005, p. 163-175.

Research output: Contribution to journalArticle

Bien, Mauo Ying ; Yien, Huey Wen ; Hseu, Shu Shya ; Wang, Jia Horng ; Kou, Yu Ru. / Instability of spontaneous breathing patterns in patients with persistent vegetative state. In: Respiratory Physiology and Neurobiology. 2005 ; Vol. 145, No. 2-3. pp. 163-175.
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