Abstract

Objective: The impact of hypnotic use on the association between insomnia and breast cancer risk remains unclear. This study examined whether insomnia increases the aforementioned risk and explored the effects of hypnotic use on this relationship. Materials and Methods: This retrospective cohort study was conducted using data retrieved from the Longitudinal Health Insurance Research Database 2010. In total, 11,021 patients with insomnia, who were categorized by hypnotic use and nonuse, were identified; 22,042 age-matched participants without insomnia were then randomly selected. Cox proportional hazards regression was used for the analyses. Results: The insomnia cohort had a higher risk of breast cancer than did the control cohort (adjusted hazard ratio [aHR] = 1.43; 95% confidence interval [CI] = 1.10-1.84). The aHR was 1.09 for insomniac with hypnotics use, 1.41 for insomniac without hypnotics use, and 0.71 for hypnotics users without insomnia (95% CIs = 0.71-1.68, 1.07-1.85, and 0.40-1.27) compared with those individuals without insomnia who did not use hypnotics. Conclusion: This nationwide population-based cohort study reveals that insomnia but not hypnotic use is associated with an increased risk of breast cancer.

Original languageEnglish
Pages (from-to)1250-1256
Number of pages7
JournalJournal of Women's Health
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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Sleep Initiation and Maintenance Disorders
Hypnotics and Sedatives
Cohort Studies
Breast Neoplasms
Population
Health Insurance
Retrospective Studies
Databases
Confidence Intervals
Research

Keywords

  • breast cancer
  • hypnotic use
  • insomnia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{cc7033ba88c34fcc86da9113a09daf55,
title = "Insomnia but Not Hypnotics Use Associates with the Risk of Breast Cancer: A Population-Based Matched Cohort Study",
abstract = "Objective: The impact of hypnotic use on the association between insomnia and breast cancer risk remains unclear. This study examined whether insomnia increases the aforementioned risk and explored the effects of hypnotic use on this relationship. Materials and Methods: This retrospective cohort study was conducted using data retrieved from the Longitudinal Health Insurance Research Database 2010. In total, 11,021 patients with insomnia, who were categorized by hypnotic use and nonuse, were identified; 22,042 age-matched participants without insomnia were then randomly selected. Cox proportional hazards regression was used for the analyses. Results: The insomnia cohort had a higher risk of breast cancer than did the control cohort (adjusted hazard ratio [aHR] = 1.43; 95{\%} confidence interval [CI] = 1.10-1.84). The aHR was 1.09 for insomniac with hypnotics use, 1.41 for insomniac without hypnotics use, and 0.71 for hypnotics users without insomnia (95{\%} CIs = 0.71-1.68, 1.07-1.85, and 0.40-1.27) compared with those individuals without insomnia who did not use hypnotics. Conclusion: This nationwide population-based cohort study reveals that insomnia but not hypnotic use is associated with an increased risk of breast cancer.",
keywords = "breast cancer, hypnotic use, insomnia",
author = "Chiu, {Hsiao Yean} and Huang, {Chun Jen} and Fan, {Yen Chun} and Tsai, {Pei Shan}",
year = "2018",
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doi = "10.1089/jwh.2017.6626",
language = "English",
volume = "27",
pages = "1250--1256",
journal = "Journal of Women's Health",
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T1 - Insomnia but Not Hypnotics Use Associates with the Risk of Breast Cancer

T2 - A Population-Based Matched Cohort Study

AU - Chiu, Hsiao Yean

AU - Huang, Chun Jen

AU - Fan, Yen Chun

AU - Tsai, Pei Shan

PY - 2018/10/1

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N2 - Objective: The impact of hypnotic use on the association between insomnia and breast cancer risk remains unclear. This study examined whether insomnia increases the aforementioned risk and explored the effects of hypnotic use on this relationship. Materials and Methods: This retrospective cohort study was conducted using data retrieved from the Longitudinal Health Insurance Research Database 2010. In total, 11,021 patients with insomnia, who were categorized by hypnotic use and nonuse, were identified; 22,042 age-matched participants without insomnia were then randomly selected. Cox proportional hazards regression was used for the analyses. Results: The insomnia cohort had a higher risk of breast cancer than did the control cohort (adjusted hazard ratio [aHR] = 1.43; 95% confidence interval [CI] = 1.10-1.84). The aHR was 1.09 for insomniac with hypnotics use, 1.41 for insomniac without hypnotics use, and 0.71 for hypnotics users without insomnia (95% CIs = 0.71-1.68, 1.07-1.85, and 0.40-1.27) compared with those individuals without insomnia who did not use hypnotics. Conclusion: This nationwide population-based cohort study reveals that insomnia but not hypnotic use is associated with an increased risk of breast cancer.

AB - Objective: The impact of hypnotic use on the association between insomnia and breast cancer risk remains unclear. This study examined whether insomnia increases the aforementioned risk and explored the effects of hypnotic use on this relationship. Materials and Methods: This retrospective cohort study was conducted using data retrieved from the Longitudinal Health Insurance Research Database 2010. In total, 11,021 patients with insomnia, who were categorized by hypnotic use and nonuse, were identified; 22,042 age-matched participants without insomnia were then randomly selected. Cox proportional hazards regression was used for the analyses. Results: The insomnia cohort had a higher risk of breast cancer than did the control cohort (adjusted hazard ratio [aHR] = 1.43; 95% confidence interval [CI] = 1.10-1.84). The aHR was 1.09 for insomniac with hypnotics use, 1.41 for insomniac without hypnotics use, and 0.71 for hypnotics users without insomnia (95% CIs = 0.71-1.68, 1.07-1.85, and 0.40-1.27) compared with those individuals without insomnia who did not use hypnotics. Conclusion: This nationwide population-based cohort study reveals that insomnia but not hypnotic use is associated with an increased risk of breast cancer.

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