Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways

Yinshen Wee, Chieh Hsiang Yang, Shau Kwaun Chen, Yu Chun Yen, Ching Shuen Wang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. Although we may consume significant amount of IP6 daily, it is unclear whether this diet will impact macrophages’ fate and function. Therefore, we characterized the underlying relationship between IP6 and macrophage polarization in this study. We specifically examined the signature gene expression profiles associated with pro- and anti-inflammatory responses, and resolution of inflammation pathways in macrophages under the influence of IP6. Interestingly, our data suggested that IP6 polarizes bone marrow-derived macrophages (BMDM) into an M2a-like subtype. Our results also demonstrated that IP6 reduces lipopolysaccharide-induced apoptosis and pro-inflammatory responses in macrophages. In contrast, the expression levels of genes related to anti-inflammatory responses and resolution of inflammation pathways are upregulated. Our findings collectively demonstrated that IP6 has profound modulation effects on macrophages, which warrant further research on the therapeutic benefits of IP6 for inflammatory diseases.

Original languageEnglish
Pages (from-to)3240-3249
Number of pages10
JournalFood Science and Nutrition
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2021

Keywords

  • anti-inflammatory
  • dietary supplement
  • formyl peptide receptor 2
  • Inositol hexaphosphate
  • lipoxygenases
  • M2a macrophages
  • macrophage polarization
  • phytic acid
  • resolution of inflammation
  • tissue repair

ASJC Scopus subject areas

  • Food Science

Fingerprint

Dive into the research topics of 'Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways'. Together they form a unique fingerprint.

Cite this