19 Citations (Scopus)

Abstract

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

Original languageEnglish
Article number4425
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - Mar 21 2014

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Renal Dialysis
Safety
Water
Dialysis Solutions
Creatinine
Nitrogen
Urine
Methyl Green
Kidney Diseases
Lighting
Sodium Chloride
Nanoparticles
Lipopolysaccharides
Dialysis
Oxidative Stress
Inflammation
Membranes
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Innovative strategy with potential to increase hemodialysis efficiency and safety. / Chen, Hsiao Chien; Lin, Hsiu Chen; Chen, Hsi Hsien; Mai, Fu Der; Liu, Yu Chuan; Lin, Chun Mao; Chang, Chun Chao; Tsai, Hui Yen; Yang, Chih Ping.

In: Scientific Reports, Vol. 4, 4425, 21.03.2014.

Research output: Contribution to journalArticle

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AU - Lin, Hsiu Chen

AU - Chen, Hsi Hsien

AU - Mai, Fu Der

AU - Liu, Yu Chuan

AU - Lin, Chun Mao

AU - Chang, Chun Chao

AU - Tsai, Hui Yen

AU - Yang, Chih Ping

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