Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis

Chih-Hwa Chen, 薛 文景(Wen-Ching Say), 葉 晉志(Chin-Chih Yeh), 潘 宏維(Horng-Wei Pan), 楊 春勇(Chung-Yeung Yang), 陳 文哲(Wen-Jer Chen), 施 俊雄(Chun-Hsiung shih)

Research output: Contribution to journalArticle

Abstract

Various synthetic materials as bone substitute have been tested with unreliable clinical application. Calcium sulfate has been used as a bone-graft substitute. Calcium phosphate is regarded to have a longer resorption period for further scaffold support. An injectable form of a calcium sulfate-calcium phosphate composite was created to be a bone substitute. This study is to evaluate the mechanical properties and histological changes in a rabbit model. The mean compression strength was 22.17 ± 1.37 Mpa. The mean bending strength was 11.19 ± 0.72 Mpa. The average setting time was 12.5 ± 0.5 min. The histological studies showed that osteoclasts could be identified with active mineral resorption associated with new-bone formation at 4 weeks. Osteoblasts could also be found adjacent to the osteoclasts indicating initiation of bone ingrowth. Extensive cellular activity at the interface between peripheral bone and the calcium sulfate-calcium phosphate bone substitute suggested active bone-ingrowth at 8 weeks. At 12 weeks, the bone defect was filled with trabecular bone. Extensive trabecular bone formation appeared in the original bone defect region. There was no fibrous tissue between the material and the bone. The injectable property of this composite made it possible to fill gaps easily and efficiently and avoid fibrous tissue ingrowth during the bone healing process. The composite provides instant mechanical support of the recipient site, which avoided early mechanical failure.
Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalJournal of Orthopedic Surgery Taiwan
Volume20
Issue number4
Publication statusPublished - 2003

Fingerprint

Bone Substitutes
Calcium Sulfate
Bone and Bones
Injections
Osteoclasts
Osteogenesis
calcium phosphate
Osteoblasts
Minerals
Rabbits
Transplants

Keywords

  • bone substitute
  • calcium sulfate
  • calcium phosphate

Cite this

Chen, C-H., 薛文景(Wen-Ching S, 葉晉志(Chin-Chih Y, 潘宏維(Horng-Wei P, 楊春勇(Chung-Yeung Y, 陳文哲(Wen-Jer C, & 施俊雄(Chun-Hsiung S (2003). Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis. Journal of Orthopedic Surgery Taiwan, 20(4), 172-177.

Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis. / Chen, Chih-Hwa; 薛文景(Wen-Ching Say); 葉晉志(Chin-Chih Yeh); 潘宏維(Horng-Wei Pan); 楊春勇(Chung-Yeung Yang); 陳文哲(Wen-Jer Chen); 施俊雄(Chun-Hsiung shih).

In: Journal of Orthopedic Surgery Taiwan, Vol. 20, No. 4, 2003, p. 172-177.

Research output: Contribution to journalArticle

Chen, C-H, 薛文景(Wen-ChingS, 葉晉志(Chin-ChihY, 潘宏維(Horng-WeiP, 楊春勇(Chung-YeungY, 陳文哲(Wen-JerC & 施俊雄(Chun-HsiungS 2003, 'Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis', Journal of Orthopedic Surgery Taiwan, vol. 20, no. 4, pp. 172-177.
Chen C-H, 薛文景(Wen-ChingS, 葉晉志(Chin-ChihY, 潘宏維(Horng-WeiP, 楊春勇(Chung-YeungY, 陳文哲(Wen-JerC et al. Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis. Journal of Orthopedic Surgery Taiwan. 2003;20(4):172-177.
Chen, Chih-Hwa ; 薛文景(Wen-Ching Say) ; 葉晉志(Chin-Chih Yeh) ; 潘宏維(Horng-Wei Pan) ; 楊春勇(Chung-Yeung Yang) ; 陳文哲(Wen-Jer Chen) ; 施俊雄(Chun-Hsiung shih). / Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis. In: Journal of Orthopedic Surgery Taiwan. 2003 ; Vol. 20, No. 4. pp. 172-177.
@article{5be5eecf2eaf41c398a5269cd98254fa,
title = "Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis",
abstract = "Various synthetic materials as bone substitute have been tested with unreliable clinical application. Calcium sulfate has been used as a bone-graft substitute. Calcium phosphate is regarded to have a longer resorption period for further scaffold support. An injectable form of a calcium sulfate-calcium phosphate composite was created to be a bone substitute. This study is to evaluate the mechanical properties and histological changes in a rabbit model. The mean compression strength was 22.17 ± 1.37 Mpa. The mean bending strength was 11.19 ± 0.72 Mpa. The average setting time was 12.5 ± 0.5 min. The histological studies showed that osteoclasts could be identified with active mineral resorption associated with new-bone formation at 4 weeks. Osteoblasts could also be found adjacent to the osteoclasts indicating initiation of bone ingrowth. Extensive cellular activity at the interface between peripheral bone and the calcium sulfate-calcium phosphate bone substitute suggested active bone-ingrowth at 8 weeks. At 12 weeks, the bone defect was filled with trabecular bone. Extensive trabecular bone formation appeared in the original bone defect region. There was no fibrous tissue between the material and the bone. The injectable property of this composite made it possible to fill gaps easily and efficiently and avoid fibrous tissue ingrowth during the bone healing process. The composite provides instant mechanical support of the recipient site, which avoided early mechanical failure.",
keywords = "bone substitute, calcium sulfate, calcium phosphate",
author = "Chih-Hwa Chen and 薛, {文景(Wen-Ching Say)} and 葉, {晉志(Chin-Chih Yeh)} and 潘, {宏維(Horng-Wei Pan)} and 楊, {春勇(Chung-Yeung Yang)} and 陳, {文哲(Wen-Jer Chen)} and 施, {俊雄(Chun-Hsiung shih)}",
year = "2003",
language = "English",
volume = "20",
pages = "172--177",
journal = "Journal of Orthopedic Surgery Taiwan",
issn = "1011-6923",
publisher = "中華民國骨科醫學會",
number = "4",

}

TY - JOUR

T1 - Injectable Calcium Sulfate-Calcium Phosphate Composite as a Bone Substitute – Material Properties And Histological Analysis

AU - Chen, Chih-Hwa

AU - 薛, 文景(Wen-Ching Say)

AU - 葉, 晉志(Chin-Chih Yeh)

AU - 潘, 宏維(Horng-Wei Pan)

AU - 楊, 春勇(Chung-Yeung Yang)

AU - 陳, 文哲(Wen-Jer Chen)

AU - 施, 俊雄(Chun-Hsiung shih)

PY - 2003

Y1 - 2003

N2 - Various synthetic materials as bone substitute have been tested with unreliable clinical application. Calcium sulfate has been used as a bone-graft substitute. Calcium phosphate is regarded to have a longer resorption period for further scaffold support. An injectable form of a calcium sulfate-calcium phosphate composite was created to be a bone substitute. This study is to evaluate the mechanical properties and histological changes in a rabbit model. The mean compression strength was 22.17 ± 1.37 Mpa. The mean bending strength was 11.19 ± 0.72 Mpa. The average setting time was 12.5 ± 0.5 min. The histological studies showed that osteoclasts could be identified with active mineral resorption associated with new-bone formation at 4 weeks. Osteoblasts could also be found adjacent to the osteoclasts indicating initiation of bone ingrowth. Extensive cellular activity at the interface between peripheral bone and the calcium sulfate-calcium phosphate bone substitute suggested active bone-ingrowth at 8 weeks. At 12 weeks, the bone defect was filled with trabecular bone. Extensive trabecular bone formation appeared in the original bone defect region. There was no fibrous tissue between the material and the bone. The injectable property of this composite made it possible to fill gaps easily and efficiently and avoid fibrous tissue ingrowth during the bone healing process. The composite provides instant mechanical support of the recipient site, which avoided early mechanical failure.

AB - Various synthetic materials as bone substitute have been tested with unreliable clinical application. Calcium sulfate has been used as a bone-graft substitute. Calcium phosphate is regarded to have a longer resorption period for further scaffold support. An injectable form of a calcium sulfate-calcium phosphate composite was created to be a bone substitute. This study is to evaluate the mechanical properties and histological changes in a rabbit model. The mean compression strength was 22.17 ± 1.37 Mpa. The mean bending strength was 11.19 ± 0.72 Mpa. The average setting time was 12.5 ± 0.5 min. The histological studies showed that osteoclasts could be identified with active mineral resorption associated with new-bone formation at 4 weeks. Osteoblasts could also be found adjacent to the osteoclasts indicating initiation of bone ingrowth. Extensive cellular activity at the interface between peripheral bone and the calcium sulfate-calcium phosphate bone substitute suggested active bone-ingrowth at 8 weeks. At 12 weeks, the bone defect was filled with trabecular bone. Extensive trabecular bone formation appeared in the original bone defect region. There was no fibrous tissue between the material and the bone. The injectable property of this composite made it possible to fill gaps easily and efficiently and avoid fibrous tissue ingrowth during the bone healing process. The composite provides instant mechanical support of the recipient site, which avoided early mechanical failure.

KW - bone substitute

KW - calcium sulfate

KW - calcium phosphate

M3 - Article

VL - 20

SP - 172

EP - 177

JO - Journal of Orthopedic Surgery Taiwan

JF - Journal of Orthopedic Surgery Taiwan

SN - 1011-6923

IS - 4

ER -