Injectable and biodegradable composite bone filler composed of poly(propylene fumarate) and calcium phosphate ceramic for vertebral augmentation procedure: An in vivo porcine study

Chang Chin Wu, Li Ho Hsu, Shoichiro Sumi, Kai Chiang Yang, Shu Hua Yang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Despite its common usage in vertebral augmentation procedures (VAPs), shortcomings of commercial polymethylmethacrylate (PMMA) still remain. Accordingly, injectable and biodegradable composite cements, which are composed of poly(propylene fumarate)/α-tricalcium/hydroxyapatite (PPF/α-TCP/HAP) and PPF/tetracalcium phosphate/dicalcium phosphate (PPF/TtCP/DCP), were developed. A porcine model was used and cylindrical holes in critical size were created at the center of the lateral cortex of vertebral bodies of the lumbar spine. A fixed volume of testing materials and PMMA were randomly injected into the defects. Results showed that both composite groups had a comparable radiolucency as PMMA but a significantly lower setting temperature. Histological inspections revealed new bone formation and remodeling along the border of the two composite cements. New bone substitution and irregular sclerotic bone mantles were found along the composite cements but not in the PMMA group. Radiological and histological changes were observed in the two composite groups and these modifications were diminished along the block boundaries. These findings imply gradual substitution of decomposed composite by new bone formation, which could not be found around the PMMA block. Comparing PPF/α-TCP/HAP with the PPF/TtCP/DCP cement block, smaller particles that were spreading out were observed in the TtCP/DCP group, which represents rapid degradability. In conclusion, the composite cements have advantages such as a low setting temperature, radio-opacity, biodegradability, and osteoconductivity. The injectable PPF/calcium phosphate ceramic composite has the potential to be used in VAPs.

Original languageEnglish
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
DOIs
Publication statusPublished - 2017

Fingerprint

Calcium phosphate
Fillers
Polypropylenes
Bone
Polymethyl Methacrylate
Composite materials
Phosphates
Bone cement
Cements
Substitution reactions
Materials testing
poly(propylene fumarate)
calcium phosphate
Biodegradability
Opacity
Durapatite
Hydroxyapatite
Inspection
Temperature
Defects

Keywords

  • Calcium phosphate ceramic
  • Injectable bone cement
  • Poly(propylene fumarate)
  • Polymethylmethacrylate
  • Vertebral augmentation procedure

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

@article{b3ec89a7246c4723b094862f644ade74,
title = "Injectable and biodegradable composite bone filler composed of poly(propylene fumarate) and calcium phosphate ceramic for vertebral augmentation procedure: An in vivo porcine study",
abstract = "Despite its common usage in vertebral augmentation procedures (VAPs), shortcomings of commercial polymethylmethacrylate (PMMA) still remain. Accordingly, injectable and biodegradable composite cements, which are composed of poly(propylene fumarate)/α-tricalcium/hydroxyapatite (PPF/α-TCP/HAP) and PPF/tetracalcium phosphate/dicalcium phosphate (PPF/TtCP/DCP), were developed. A porcine model was used and cylindrical holes in critical size were created at the center of the lateral cortex of vertebral bodies of the lumbar spine. A fixed volume of testing materials and PMMA were randomly injected into the defects. Results showed that both composite groups had a comparable radiolucency as PMMA but a significantly lower setting temperature. Histological inspections revealed new bone formation and remodeling along the border of the two composite cements. New bone substitution and irregular sclerotic bone mantles were found along the composite cements but not in the PMMA group. Radiological and histological changes were observed in the two composite groups and these modifications were diminished along the block boundaries. These findings imply gradual substitution of decomposed composite by new bone formation, which could not be found around the PMMA block. Comparing PPF/α-TCP/HAP with the PPF/TtCP/DCP cement block, smaller particles that were spreading out were observed in the TtCP/DCP group, which represents rapid degradability. In conclusion, the composite cements have advantages such as a low setting temperature, radio-opacity, biodegradability, and osteoconductivity. The injectable PPF/calcium phosphate ceramic composite has the potential to be used in VAPs.",
keywords = "Calcium phosphate ceramic, Injectable bone cement, Poly(propylene fumarate), Polymethylmethacrylate, Vertebral augmentation procedure",
author = "Wu, {Chang Chin} and Hsu, {Li Ho} and Shoichiro Sumi and Yang, {Kai Chiang} and Yang, {Shu Hua}",
year = "2017",
doi = "10.1002/jbm.b.33678",
language = "English",
journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",
issn = "1552-4973",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Injectable and biodegradable composite bone filler composed of poly(propylene fumarate) and calcium phosphate ceramic for vertebral augmentation procedure

T2 - An in vivo porcine study

AU - Wu, Chang Chin

AU - Hsu, Li Ho

AU - Sumi, Shoichiro

AU - Yang, Kai Chiang

AU - Yang, Shu Hua

PY - 2017

Y1 - 2017

N2 - Despite its common usage in vertebral augmentation procedures (VAPs), shortcomings of commercial polymethylmethacrylate (PMMA) still remain. Accordingly, injectable and biodegradable composite cements, which are composed of poly(propylene fumarate)/α-tricalcium/hydroxyapatite (PPF/α-TCP/HAP) and PPF/tetracalcium phosphate/dicalcium phosphate (PPF/TtCP/DCP), were developed. A porcine model was used and cylindrical holes in critical size were created at the center of the lateral cortex of vertebral bodies of the lumbar spine. A fixed volume of testing materials and PMMA were randomly injected into the defects. Results showed that both composite groups had a comparable radiolucency as PMMA but a significantly lower setting temperature. Histological inspections revealed new bone formation and remodeling along the border of the two composite cements. New bone substitution and irregular sclerotic bone mantles were found along the composite cements but not in the PMMA group. Radiological and histological changes were observed in the two composite groups and these modifications were diminished along the block boundaries. These findings imply gradual substitution of decomposed composite by new bone formation, which could not be found around the PMMA block. Comparing PPF/α-TCP/HAP with the PPF/TtCP/DCP cement block, smaller particles that were spreading out were observed in the TtCP/DCP group, which represents rapid degradability. In conclusion, the composite cements have advantages such as a low setting temperature, radio-opacity, biodegradability, and osteoconductivity. The injectable PPF/calcium phosphate ceramic composite has the potential to be used in VAPs.

AB - Despite its common usage in vertebral augmentation procedures (VAPs), shortcomings of commercial polymethylmethacrylate (PMMA) still remain. Accordingly, injectable and biodegradable composite cements, which are composed of poly(propylene fumarate)/α-tricalcium/hydroxyapatite (PPF/α-TCP/HAP) and PPF/tetracalcium phosphate/dicalcium phosphate (PPF/TtCP/DCP), were developed. A porcine model was used and cylindrical holes in critical size were created at the center of the lateral cortex of vertebral bodies of the lumbar spine. A fixed volume of testing materials and PMMA were randomly injected into the defects. Results showed that both composite groups had a comparable radiolucency as PMMA but a significantly lower setting temperature. Histological inspections revealed new bone formation and remodeling along the border of the two composite cements. New bone substitution and irregular sclerotic bone mantles were found along the composite cements but not in the PMMA group. Radiological and histological changes were observed in the two composite groups and these modifications were diminished along the block boundaries. These findings imply gradual substitution of decomposed composite by new bone formation, which could not be found around the PMMA block. Comparing PPF/α-TCP/HAP with the PPF/TtCP/DCP cement block, smaller particles that were spreading out were observed in the TtCP/DCP group, which represents rapid degradability. In conclusion, the composite cements have advantages such as a low setting temperature, radio-opacity, biodegradability, and osteoconductivity. The injectable PPF/calcium phosphate ceramic composite has the potential to be used in VAPs.

KW - Calcium phosphate ceramic

KW - Injectable bone cement

KW - Poly(propylene fumarate)

KW - Polymethylmethacrylate

KW - Vertebral augmentation procedure

UR - http://www.scopus.com/inward/record.url?scp=84979079589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979079589&partnerID=8YFLogxK

U2 - 10.1002/jbm.b.33678

DO - 10.1002/jbm.b.33678

M3 - Article

AN - SCOPUS:84979079589

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

SN - 1552-4973

ER -