Initial drug resistance of Mycobacterium tuberculosis in Taiwan

Ming Chih Yu, Jen Suo, Chen Yuan Chiang, Kuan Jen Bai, Tao Ping Lin, Kwen Tay Luh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The prevalence and mortality rate of pulmonary tuberculosis in adults are high in Taiwan. Because the emergence of drug- resistant tuberculosis is one of the major causes of this sustained high tuberculosis mortality, surveillance of initial drug resistance is important. We tested Mycobacterium tuberculosis isolates from 1,935 newly diagnosed tuberculosis patients from January 1990 through December 1995 at the Taiwan Provincial Chronic Disease Control Bureau. The overall initial drug resistance rate was 12.3%: 8.7% of isolates were resistant to only one drug, 2.6% to two drugs, 0.7% to three drugs, and 0.3% to four drugs. The resistance rates to individual drugs were: streptomycin, 5.7%; isoniazid, 9.2%; ethambutol, 0.7%; and rifampin, 1.5%. The frequency of multidrug-resistant M. tuberculosis (resistant to at least isoniazid and rifampin) was 1.2%. In view of the high initial isoniazid resistance rate and low initial ethambutol resistance rate, ethambutol should be added to the regimen for the initial treatment of tuberculosis in Taiwan. The emergence of multidrug- resistant M. tuberculosis is ominous and should be considered when treating patients in Taiwan.

Original languageEnglish
Pages (from-to)890-894
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume96
Issue number11
Publication statusPublished - Nov 1997
Externally publishedYes

Fingerprint

Taiwan
Mycobacterium tuberculosis
Drug Resistance
Ethambutol
Multidrug-Resistant Tuberculosis
Isoniazid
Tuberculosis
Pharmaceutical Preparations
Rifampin
Mycobacterium
Mortality
Streptomycin
Pulmonary Tuberculosis
Chronic Disease
Therapeutics

Keywords

  • Drug resistance
  • Multidrug resistant
  • Mycobacterium tuberculosis
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Initial drug resistance of Mycobacterium tuberculosis in Taiwan. / Yu, Ming Chih; Suo, Jen; Chiang, Chen Yuan; Bai, Kuan Jen; Lin, Tao Ping; Luh, Kwen Tay.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 96, No. 11, 11.1997, p. 890-894.

Research output: Contribution to journalArticle

@article{262a9ab22eab44b8975cddfac362ceb5,
title = "Initial drug resistance of Mycobacterium tuberculosis in Taiwan",
abstract = "The prevalence and mortality rate of pulmonary tuberculosis in adults are high in Taiwan. Because the emergence of drug- resistant tuberculosis is one of the major causes of this sustained high tuberculosis mortality, surveillance of initial drug resistance is important. We tested Mycobacterium tuberculosis isolates from 1,935 newly diagnosed tuberculosis patients from January 1990 through December 1995 at the Taiwan Provincial Chronic Disease Control Bureau. The overall initial drug resistance rate was 12.3{\%}: 8.7{\%} of isolates were resistant to only one drug, 2.6{\%} to two drugs, 0.7{\%} to three drugs, and 0.3{\%} to four drugs. The resistance rates to individual drugs were: streptomycin, 5.7{\%}; isoniazid, 9.2{\%}; ethambutol, 0.7{\%}; and rifampin, 1.5{\%}. The frequency of multidrug-resistant M. tuberculosis (resistant to at least isoniazid and rifampin) was 1.2{\%}. In view of the high initial isoniazid resistance rate and low initial ethambutol resistance rate, ethambutol should be added to the regimen for the initial treatment of tuberculosis in Taiwan. The emergence of multidrug- resistant M. tuberculosis is ominous and should be considered when treating patients in Taiwan.",
keywords = "Drug resistance, Multidrug resistant, Mycobacterium tuberculosis, Tuberculosis",
author = "Yu, {Ming Chih} and Jen Suo and Chiang, {Chen Yuan} and Bai, {Kuan Jen} and Lin, {Tao Ping} and Luh, {Kwen Tay}",
year = "1997",
month = "11",
language = "English",
volume = "96",
pages = "890--894",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "11",

}

TY - JOUR

T1 - Initial drug resistance of Mycobacterium tuberculosis in Taiwan

AU - Yu, Ming Chih

AU - Suo, Jen

AU - Chiang, Chen Yuan

AU - Bai, Kuan Jen

AU - Lin, Tao Ping

AU - Luh, Kwen Tay

PY - 1997/11

Y1 - 1997/11

N2 - The prevalence and mortality rate of pulmonary tuberculosis in adults are high in Taiwan. Because the emergence of drug- resistant tuberculosis is one of the major causes of this sustained high tuberculosis mortality, surveillance of initial drug resistance is important. We tested Mycobacterium tuberculosis isolates from 1,935 newly diagnosed tuberculosis patients from January 1990 through December 1995 at the Taiwan Provincial Chronic Disease Control Bureau. The overall initial drug resistance rate was 12.3%: 8.7% of isolates were resistant to only one drug, 2.6% to two drugs, 0.7% to three drugs, and 0.3% to four drugs. The resistance rates to individual drugs were: streptomycin, 5.7%; isoniazid, 9.2%; ethambutol, 0.7%; and rifampin, 1.5%. The frequency of multidrug-resistant M. tuberculosis (resistant to at least isoniazid and rifampin) was 1.2%. In view of the high initial isoniazid resistance rate and low initial ethambutol resistance rate, ethambutol should be added to the regimen for the initial treatment of tuberculosis in Taiwan. The emergence of multidrug- resistant M. tuberculosis is ominous and should be considered when treating patients in Taiwan.

AB - The prevalence and mortality rate of pulmonary tuberculosis in adults are high in Taiwan. Because the emergence of drug- resistant tuberculosis is one of the major causes of this sustained high tuberculosis mortality, surveillance of initial drug resistance is important. We tested Mycobacterium tuberculosis isolates from 1,935 newly diagnosed tuberculosis patients from January 1990 through December 1995 at the Taiwan Provincial Chronic Disease Control Bureau. The overall initial drug resistance rate was 12.3%: 8.7% of isolates were resistant to only one drug, 2.6% to two drugs, 0.7% to three drugs, and 0.3% to four drugs. The resistance rates to individual drugs were: streptomycin, 5.7%; isoniazid, 9.2%; ethambutol, 0.7%; and rifampin, 1.5%. The frequency of multidrug-resistant M. tuberculosis (resistant to at least isoniazid and rifampin) was 1.2%. In view of the high initial isoniazid resistance rate and low initial ethambutol resistance rate, ethambutol should be added to the regimen for the initial treatment of tuberculosis in Taiwan. The emergence of multidrug- resistant M. tuberculosis is ominous and should be considered when treating patients in Taiwan.

KW - Drug resistance

KW - Multidrug resistant

KW - Mycobacterium tuberculosis

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=0031413265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031413265&partnerID=8YFLogxK

M3 - Article

C2 - 9409122

AN - SCOPUS:0031413265

VL - 96

SP - 890

EP - 894

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 11

ER -