Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation

Chi Feng Pan, Ming Yi Shen, Chih Jen Wu, George Hsiao, Duen Suey Chou, Joen Rong Sheu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Gabapentin (Neurontin) is an analogue of gamma-aminobutyric acid (GABA) that is effective against partial seizures. Gabapentin has been reported to modulate serotonin release from platelets, but the effects of gabapentin on platelet activation have not been explored. In this study, gabapentin concentration-dependently (60-240 μM) inhibited platelet aggregation in washed platelets stimulated by collagen (1 μg mL-1), ADP (20 μM) and arachidonic acid (60 μM). Gabapentin (120 and 240 μM) also concentration-dependently inhibited collagen (1 μg mL-1)-induced phosphoinositide breakdown, intracellular Ca2+ mobilization, thromboxane A2 formation, and p38 MAPK phosphorylation in human platelets. In conclusion, the most important findings of this study suggest that gabapentin inhibits platelet aggregation, at least in part, through the phospholipase C-inositol 1,4,5-trisphosphate-thromboxane A2-Ca 2+ pathway. Thus, it is possible that gabapentin treatment, alone or in combination with other antiplatelet drugs, may induce or potentiate inhibition of platelet aggregation, which may affect haemostasis in-vivo.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalJournal of Pharmacy and Pharmacology
Volume59
Issue number9
DOIs
Publication statusPublished - Sep 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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