Inhibitory effects of polyphenolic catechins from Chinese green tea on HIV reverse transcriptase activity

C. W. Chang, F. L. Hsu, J. Y. Lin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti-Kaun-Yin (Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The concentrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68 μM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic analysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n(dT)12-18 and noncompetitive inhibitors to dTTP.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalJournal of Biomedical Science
Volume1
Issue number3
DOIs
Publication statusPublished - Jun 1994

Keywords

  • HIV reverse transcriptase activity
  • Polyphenolic catechins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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