Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth

Ting Kai Leung, Chin Feng Chan, Ping Shan Lai, Chih Hui Yang, Chia Yen Hsu, Yung Sheng Lin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The biological effects of specific wavelengths, so-called far-infrared radiation produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- 2 ′, 7 ′ -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.

Original languageEnglish
Article number646845
JournalInternational Journal of Photoenergy
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

biological effects
Nitric oxide
Cell growth
nitric oxide
Ceramic materials
Nitric Oxide
Irradiation
ceramics
far infrared radiation
Infrared radiation
body temperature
irradiation
HSP70 Heat-Shock Proteins
cells
organisms
Reactive Oxygen Species
shock
Cells
proteins
Proteins

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)

Cite this

Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth. / Leung, Ting Kai; Chan, Chin Feng; Lai, Ping Shan; Yang, Chih Hui; Hsu, Chia Yen; Lin, Yung Sheng.

In: International Journal of Photoenergy, Vol. 2012, 646845, 2012.

Research output: Contribution to journalArticle

Leung, Ting Kai ; Chan, Chin Feng ; Lai, Ping Shan ; Yang, Chih Hui ; Hsu, Chia Yen ; Lin, Yung Sheng. / Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth. In: International Journal of Photoenergy. 2012 ; Vol. 2012.
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