Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells

W.-L. Hung, B.-Y. Hsu, Y.-C. Tung, C.-T. Ho, L.S. Hwang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common form of dementia. It is characterized by aggregation of amyloid plaques and neurofibrillary tangles. The neurotoxic action of amyloid β-peptide (Aβ) involves formation of reactive oxygen species. Trans fatty acids (TFAs) are not only exogenously derived from dietary food, but also endogenously formed by free radicals. Thus, we utilized the PC-12 cell model to investigate the correlation between radical stress and endogenous formed TFAs. The results showed that thiyl radicals significantly increased TFA formation in PC-12 cells in both pre-treatment and co-treatment experiments. It was also found that retinol acetate significantly decreased thiyl radical-catalysed TFA formation in PC-12 cells. The anti-isomerization activity of retinol acetate resulted, at least in part, from its high absorption efficiency by PC-12 cells and its thiyl radical scavenging activity. Therefore, retinol acetate may serve as a potential antioxidant for functional foods against TFA formation during pathogenesis of AD. © 2015 Elsevier Ltd.
Original languageEnglish
Pages (from-to)212-222
Number of pages11
JournalJournal of Functional Foods
Volume21
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Trans Fatty Acids
trans fatty acids
Vitamins
vitamins
Antioxidants
antioxidants
vitamin A
acetates
amyloid
Alzheimer disease
cells
Alzheimer Disease
Functional Food
Neurofibrillary Tangles
dementia
isomerization
Amyloid Plaques
Amyloid
functional foods
Free Radicals

Keywords

  • Alzheimer's disease
  • Retinol acetate
  • Thiyl radicals
  • Trans fatty acids

Cite this

Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells. / Hung, W.-L.; Hsu, B.-Y.; Tung, Y.-C.; Ho, C.-T.; Hwang, L.S.

In: Journal of Functional Foods, Vol. 21, 2016, p. 212-222.

Research output: Contribution to journalArticle

@article{7e4f71ef175840d594e710e1c00f4945,
title = "Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells",
abstract = "Alzheimer's disease (AD) is the most common form of dementia. It is characterized by aggregation of amyloid plaques and neurofibrillary tangles. The neurotoxic action of amyloid β-peptide (Aβ) involves formation of reactive oxygen species. Trans fatty acids (TFAs) are not only exogenously derived from dietary food, but also endogenously formed by free radicals. Thus, we utilized the PC-12 cell model to investigate the correlation between radical stress and endogenous formed TFAs. The results showed that thiyl radicals significantly increased TFA formation in PC-12 cells in both pre-treatment and co-treatment experiments. It was also found that retinol acetate significantly decreased thiyl radical-catalysed TFA formation in PC-12 cells. The anti-isomerization activity of retinol acetate resulted, at least in part, from its high absorption efficiency by PC-12 cells and its thiyl radical scavenging activity. Therefore, retinol acetate may serve as a potential antioxidant for functional foods against TFA formation during pathogenesis of AD. {\circledC} 2015 Elsevier Ltd.",
keywords = "Alzheimer's disease, Retinol acetate, Thiyl radicals, Trans fatty acids",
author = "W.-L. Hung and B.-Y. Hsu and Y.-C. Tung and C.-T. Ho and L.S. Hwang",
note = "引用次數:5 Export Date: 19 September 2018 通訊地址: Ho, C.-T.; Department of Food Science, Rutgers University, 65 Dudley Rd., United States; 電子郵件: ho@aesop.rutgers.edu 出資詳情: MOST, Ministry of Science and Technology, Taiwan 出資詳情: 1007898, NIFA, National Institute of Food and Agriculture 出資詳情: 99-2628-B-02-015-MY3 出資正文: This study was supported by a research grant, NSC 99-2628-B-02-015-MY3 , from the Ministry of Science and Technology , Taiwan. It is also partially supported by the USDA National Institute of Food and Agriculture , Hatch project 1007898 . 參考文獻: Abedinzadeh, Z., Sulfur-centered reactive intermediates derived from the oxidation of sulfur compounds of biological interest (2001) Canadian Journal of Physiology and Pharmacology, 79 (2), pp. 166-170; Balazy, M., Poff, C.D., Biological nitration of arachidonic acid (2004) Current Vascular Pharmacology, 2 (1), pp. 81-93; Barata-Vallejo, S., Ferreri, C., Postigo, A., Chatgilialoglu, C., Radiation chemical studies of methionine in aqueous solution: Understanding the role of molecular oxygen (2010) Chemical Research in Toxicology, 23 (1), pp. 258-263; Bendsen, N.T., Christensen, R., Bartels, E.M., Astrup, A., Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: A systematic review and meta-analysis of cohort studies (2011) European Journal of Clinical Nutrition, 65 (7), pp. 773-783; Chatgilialoglu, C., Ferreri, C., Lykakis, I.N., Wardman, P., Trans-fatty acids and radical stress: What are the real culprits? (2006) Bioorganic and Medicinal Chemistry, 14 (18), pp. 6144-6148; Chatgilialoglu, C., Ferreri, C., Melchiorre, M., Sansone, A., Torreggiani, A., Lipid geometrical isomerism: From chemistry to biology and diagnostics (2014) Chemical Reviews, 114 (1), pp. 255-284; Chatgilialoglu, C., Ferreri, C., Torreggiani, A., Salzano, A.M., Renzone, G., Scaloni, A., Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins (2011) Journal of Proteomics, 74 (11), pp. 2264-2273; Chatgilialoglu, C., Zambonin, L., Altieri, A., Ferreri, C., Mulazzani, Q.G., Landi, L., Geometrical isomerism of monounsaturated fatty acids: Thiyl radical catalysis and influence of antioxidant vitamins (2002) Free Radical Biology & Medicine, 33 (12), pp. 1681-1692; Cort, A., Ozben, T., Sansone, A., Barata-Vallejo, S., Chatgilialoglu, C., Ferreri, C., Bleomycin-induced trans lipid formation in cell membranes and in liposome models (2015) Organic & Biomolecular Chemistry, 13 (4), pp. 1100-1105; Ferreri, C., Chatgilialoglu, C., Torreggiani, A., Salzamo, A.M., Renzone, G., Scaloni, A., The reductive desulfurization of Met and Cys residues in bovine RNase A is associated with trans lipids formation in a mimetic model of biological membranes (2008) Journal of Proteome Research, 7 (5), pp. 2007-2015; Ferreri, C., Kratzsch, S., Brede, O., Marciniak, B., Chatgilialoglu, C., Trans lipid formation induced by thiols in human monocytic leukemia cells (2005) Free Radical Biology & Medicine, 38 (9), pp. 1180-1187; Ferreri, C., Samadi, A., Sassatelli, F., Landi, L., Chatgilialoglu, C., Regioselective cis-trans isomerization of arachidonic double bonds by thiyl radicals: The influence of phospholipid supramolecular organization (2004) Journal of the American Chemical Society, 126 (4), pp. 1063-1072; Foehr, E.D., Lin, X., O'Mahony, A., Geleziunas, R., Bradshaw, R.A., Greene, W.C., NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells (2000) Journal of Neuroscience, 20 (20), pp. 7556-7563; Folch, J., Lees, M., Sloane Stanley, G.H., A simple method for the isolation and purification of total lipides from animal tissues (1957) The Journal of Biological Chemistry, 226 (1), pp. 497-509; Ganguly, R., Pierce, G.N., The toxicity of dietary trans fats (2015) Food and Chemical Toxicology, 78C, pp. 170-176; Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., Gage, F.H., Mechanisms underlying inflammation in neurodegeneration (2010) Cell, 140 (6), pp. 918-934; Greene, L.A., Tischler, A.S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor (1976) Proceedings of the National Academy of Sciences of the United States of America, 73 (7), pp. 2424-2428; Haass, C., Selkoe, D.J., Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide (2007) Nature Reviews. Molecular Cell Biology, 8 (2), pp. 101-112; Hauff, S., Vetter, W., Quantitation of cis- and trans-monounsaturated fatty acids in dairy products and cod liver oil by mass spectrometry in the selected ion monitoring mode (2009) Journal of Agricultural and Food Chemistry, 57 (9), pp. 3423-3430; Horrobin, D.F., Fatty-acid metabolism in health and disease - The role of delta-6-desaturase (1993) American Journal of Clinical Nutrition, 57 (5), pp. 732-737; Hou, R.R., Chen, J.Z., Chen, H., Kang, X.G., Li, M.G., Wang, B.R., Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells (2008) Cell Biology International, 32 (1), pp. 22-30; Hsu, B.Y., Hung, W.L., Ho, C.T., Cheng, I.H., Hwang, L.S., Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice (2015) Journal of Functional Foods, 16, pp. 378-385; Hu, F.B., Stampfer, M.J., Manson, J.E., Rimm, E., Colditz, G.A., Rosner, B.A., Hennekens, C.H., Willett, W.C., Dietary fat intake and the risk of coronary heart disease in women (1997) New England Journal of Medicine, 337 (21), pp. 1491-1499; Hung, W.L., Ho, C.T., Hwang, L.S., Inhibitory activity of natural occurring antioxidants on thiyl radical-induced trans-arachidonic acid formation (2011) Journal of Agricultural and Food Chemistry, 59 (5), pp. 1968-1973; Jang, J.H., Surh, Y.J., Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death (2003) Free Radical Biology & Medicine, 34 (8), pp. 1100-1110; Jang, J.H., Surh, Y.J., Beta-amyloid-induced apoptosis is associated with cyclooxygenase-up-regulation via the mitogen-activated protein kinase-NF-kappa B signaling pathway (2005) Free Radical Biology and Medicine, 38 (12), pp. 1604-1613; Kadlcik, V., Sicard-Roselli, C., Houee-Levin, C., Kodicek, M., Ferreri, C., Chatgilialoglu, C., Reductive modification of a methionine residue in the amyloid-beta peptide (2006) Angewandte Chemie, International Edition in English, 45 (16), pp. 2595-2598; Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Ichijo, H., Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation (2005) Cell Death and Differentiation, 12 (1), pp. 19-24; Kim, D.S., Park, S.Y., Kim, J.K., Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult (2001) Neuroscience Letters, 303 (1), pp. 57-61; Kim, H., Youn, K., Yun, E.-Y., Hwang, J.-S., Jeong, W.-S., Ho, C.-T., Jun, M., Oleic acid ameliorates Aβ-induced inflammation by downregulation of COX-and iNOS via NFκB signaling pathway (2015) Journal of Functional Foods, 14, pp. 1-11; Lucy, J.A., Lichti, F.U., Reactions of vitamin A with acceptors of electrons. Interactions with iodine and the formation of iodide (1969) Biochemical Journal, 112 (2), pp. 231-241; Mattson, M.P., Pathways towards and away from Alzheimer's disease (2004) Nature, 430 (7000), pp. 631-639; Mazanetz, M.P., Fischer, P.M., Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases (2007) Nature Reviews Drug Discovery, 6 (6), pp. 464-479; Mozaffarian, D., Katan, M.B., Ascherio, A., Stampfer, M.J., Willett, W.C., Trans fatty acids and cardiovascular disease (2006) New England Journal of Medicine, 354 (15), pp. 1601-1613; Nakada, T., Kwee, I.L., Ellis, W.G., Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease (1990) Neuroreport, 1 (2), pp. 153-155; Oberley, L.W., Free radicals and diabetes (1988) Free Radical Biology & Medicine, 5 (2), pp. 113-124; Olson, J.A., Vitamin-and carotenoids as antioxidants in a physiological context (1993) Journal of Nutritional Science and Vitaminology, 39, pp. S57-S65; Pan, M.H., Ho, C.T., Chemopreventive effects of natural dietary compounds on cancer development (2008) Chemical Society Reviews, 37 (11), pp. 2558-2574; Salzano, A.M., Renzone, G., Scaloni, A., Torreggiani, A., Ferreri, C., Chatgilialoglu, C., Human serum albumin modifications associated with reductive radical stress (2011) Molecular BioSystems, 7 (3), pp. 889-898; Sanchez-Avila, N., Mata-Granados, J.M., Ruiz-Jimenez, J., Luque de Castro, M.D., Fast, sensitive and highly discriminant gas chromatography-mass spectrometry method for profiling analysis of fatty acids in serum (2009) Journal of Chromatography. A, 1216 (40), pp. 6864-6872; Valenzuela, R., Barrera, C., Espinosa, A., Llanos, P., Orellana, P., Videla, L.A., Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues (2015) Prostaglandins, Leukotrienes, and Essential Fatty Acids, 98, pp. 7-14; Wang, S.Y., Jiao, H., Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen (2000) Journal of Agricultural and Food Chemistry, 48 (11), pp. 5677-5684; Yang, B., Chen, H.Q., Stanton, C., Ross, R.P., Zhang, H., Chen, Y.Q., Chen, W., Review of the roles of conjugated linoleic acid in health and disease (2015) Journal of Functional Foods, 15, pp. 314-325",
year = "2016",
doi = "10.1016/j.jff.2015.12.005",
language = "English",
volume = "21",
pages = "212--222",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells

AU - Hung, W.-L.

AU - Hsu, B.-Y.

AU - Tung, Y.-C.

AU - Ho, C.-T.

AU - Hwang, L.S.

N1 - 引用次數:5 Export Date: 19 September 2018 通訊地址: Ho, C.-T.; Department of Food Science, Rutgers University, 65 Dudley Rd., United States; 電子郵件: ho@aesop.rutgers.edu 出資詳情: MOST, Ministry of Science and Technology, Taiwan 出資詳情: 1007898, NIFA, National Institute of Food and Agriculture 出資詳情: 99-2628-B-02-015-MY3 出資正文: This study was supported by a research grant, NSC 99-2628-B-02-015-MY3 , from the Ministry of Science and Technology , Taiwan. It is also partially supported by the USDA National Institute of Food and Agriculture , Hatch project 1007898 . 參考文獻: Abedinzadeh, Z., Sulfur-centered reactive intermediates derived from the oxidation of sulfur compounds of biological interest (2001) Canadian Journal of Physiology and Pharmacology, 79 (2), pp. 166-170; Balazy, M., Poff, C.D., Biological nitration of arachidonic acid (2004) Current Vascular Pharmacology, 2 (1), pp. 81-93; Barata-Vallejo, S., Ferreri, C., Postigo, A., Chatgilialoglu, C., Radiation chemical studies of methionine in aqueous solution: Understanding the role of molecular oxygen (2010) Chemical Research in Toxicology, 23 (1), pp. 258-263; Bendsen, N.T., Christensen, R., Bartels, E.M., Astrup, A., Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: A systematic review and meta-analysis of cohort studies (2011) European Journal of Clinical Nutrition, 65 (7), pp. 773-783; Chatgilialoglu, C., Ferreri, C., Lykakis, I.N., Wardman, P., Trans-fatty acids and radical stress: What are the real culprits? (2006) Bioorganic and Medicinal Chemistry, 14 (18), pp. 6144-6148; Chatgilialoglu, C., Ferreri, C., Melchiorre, M., Sansone, A., Torreggiani, A., Lipid geometrical isomerism: From chemistry to biology and diagnostics (2014) Chemical Reviews, 114 (1), pp. 255-284; Chatgilialoglu, C., Ferreri, C., Torreggiani, A., Salzano, A.M., Renzone, G., Scaloni, A., Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins (2011) Journal of Proteomics, 74 (11), pp. 2264-2273; Chatgilialoglu, C., Zambonin, L., Altieri, A., Ferreri, C., Mulazzani, Q.G., Landi, L., Geometrical isomerism of monounsaturated fatty acids: Thiyl radical catalysis and influence of antioxidant vitamins (2002) Free Radical Biology & Medicine, 33 (12), pp. 1681-1692; Cort, A., Ozben, T., Sansone, A., Barata-Vallejo, S., Chatgilialoglu, C., Ferreri, C., Bleomycin-induced trans lipid formation in cell membranes and in liposome models (2015) Organic & Biomolecular Chemistry, 13 (4), pp. 1100-1105; Ferreri, C., Chatgilialoglu, C., Torreggiani, A., Salzamo, A.M., Renzone, G., Scaloni, A., The reductive desulfurization of Met and Cys residues in bovine RNase A is associated with trans lipids formation in a mimetic model of biological membranes (2008) Journal of Proteome Research, 7 (5), pp. 2007-2015; Ferreri, C., Kratzsch, S., Brede, O., Marciniak, B., Chatgilialoglu, C., Trans lipid formation induced by thiols in human monocytic leukemia cells (2005) Free Radical Biology & Medicine, 38 (9), pp. 1180-1187; Ferreri, C., Samadi, A., Sassatelli, F., Landi, L., Chatgilialoglu, C., Regioselective cis-trans isomerization of arachidonic double bonds by thiyl radicals: The influence of phospholipid supramolecular organization (2004) Journal of the American Chemical Society, 126 (4), pp. 1063-1072; Foehr, E.D., Lin, X., O'Mahony, A., Geleziunas, R., Bradshaw, R.A., Greene, W.C., NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells (2000) Journal of Neuroscience, 20 (20), pp. 7556-7563; Folch, J., Lees, M., Sloane Stanley, G.H., A simple method for the isolation and purification of total lipides from animal tissues (1957) The Journal of Biological Chemistry, 226 (1), pp. 497-509; Ganguly, R., Pierce, G.N., The toxicity of dietary trans fats (2015) Food and Chemical Toxicology, 78C, pp. 170-176; Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., Gage, F.H., Mechanisms underlying inflammation in neurodegeneration (2010) Cell, 140 (6), pp. 918-934; Greene, L.A., Tischler, A.S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor (1976) Proceedings of the National Academy of Sciences of the United States of America, 73 (7), pp. 2424-2428; Haass, C., Selkoe, D.J., Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide (2007) Nature Reviews. Molecular Cell Biology, 8 (2), pp. 101-112; Hauff, S., Vetter, W., Quantitation of cis- and trans-monounsaturated fatty acids in dairy products and cod liver oil by mass spectrometry in the selected ion monitoring mode (2009) Journal of Agricultural and Food Chemistry, 57 (9), pp. 3423-3430; Horrobin, D.F., Fatty-acid metabolism in health and disease - The role of delta-6-desaturase (1993) American Journal of Clinical Nutrition, 57 (5), pp. 732-737; Hou, R.R., Chen, J.Z., Chen, H., Kang, X.G., Li, M.G., Wang, B.R., Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells (2008) Cell Biology International, 32 (1), pp. 22-30; Hsu, B.Y., Hung, W.L., Ho, C.T., Cheng, I.H., Hwang, L.S., Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice (2015) Journal of Functional Foods, 16, pp. 378-385; Hu, F.B., Stampfer, M.J., Manson, J.E., Rimm, E., Colditz, G.A., Rosner, B.A., Hennekens, C.H., Willett, W.C., Dietary fat intake and the risk of coronary heart disease in women (1997) New England Journal of Medicine, 337 (21), pp. 1491-1499; Hung, W.L., Ho, C.T., Hwang, L.S., Inhibitory activity of natural occurring antioxidants on thiyl radical-induced trans-arachidonic acid formation (2011) Journal of Agricultural and Food Chemistry, 59 (5), pp. 1968-1973; Jang, J.H., Surh, Y.J., Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death (2003) Free Radical Biology & Medicine, 34 (8), pp. 1100-1110; Jang, J.H., Surh, Y.J., Beta-amyloid-induced apoptosis is associated with cyclooxygenase-up-regulation via the mitogen-activated protein kinase-NF-kappa B signaling pathway (2005) Free Radical Biology and Medicine, 38 (12), pp. 1604-1613; Kadlcik, V., Sicard-Roselli, C., Houee-Levin, C., Kodicek, M., Ferreri, C., Chatgilialoglu, C., Reductive modification of a methionine residue in the amyloid-beta peptide (2006) Angewandte Chemie, International Edition in English, 45 (16), pp. 2595-2598; Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Ichijo, H., Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation (2005) Cell Death and Differentiation, 12 (1), pp. 19-24; Kim, D.S., Park, S.Y., Kim, J.K., Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult (2001) Neuroscience Letters, 303 (1), pp. 57-61; Kim, H., Youn, K., Yun, E.-Y., Hwang, J.-S., Jeong, W.-S., Ho, C.-T., Jun, M., Oleic acid ameliorates Aβ-induced inflammation by downregulation of COX-and iNOS via NFκB signaling pathway (2015) Journal of Functional Foods, 14, pp. 1-11; Lucy, J.A., Lichti, F.U., Reactions of vitamin A with acceptors of electrons. Interactions with iodine and the formation of iodide (1969) Biochemical Journal, 112 (2), pp. 231-241; Mattson, M.P., Pathways towards and away from Alzheimer's disease (2004) Nature, 430 (7000), pp. 631-639; Mazanetz, M.P., Fischer, P.M., Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases (2007) Nature Reviews Drug Discovery, 6 (6), pp. 464-479; Mozaffarian, D., Katan, M.B., Ascherio, A., Stampfer, M.J., Willett, W.C., Trans fatty acids and cardiovascular disease (2006) New England Journal of Medicine, 354 (15), pp. 1601-1613; Nakada, T., Kwee, I.L., Ellis, W.G., Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease (1990) Neuroreport, 1 (2), pp. 153-155; Oberley, L.W., Free radicals and diabetes (1988) Free Radical Biology & Medicine, 5 (2), pp. 113-124; Olson, J.A., Vitamin-and carotenoids as antioxidants in a physiological context (1993) Journal of Nutritional Science and Vitaminology, 39, pp. S57-S65; Pan, M.H., Ho, C.T., Chemopreventive effects of natural dietary compounds on cancer development (2008) Chemical Society Reviews, 37 (11), pp. 2558-2574; Salzano, A.M., Renzone, G., Scaloni, A., Torreggiani, A., Ferreri, C., Chatgilialoglu, C., Human serum albumin modifications associated with reductive radical stress (2011) Molecular BioSystems, 7 (3), pp. 889-898; Sanchez-Avila, N., Mata-Granados, J.M., Ruiz-Jimenez, J., Luque de Castro, M.D., Fast, sensitive and highly discriminant gas chromatography-mass spectrometry method for profiling analysis of fatty acids in serum (2009) Journal of Chromatography. A, 1216 (40), pp. 6864-6872; Valenzuela, R., Barrera, C., Espinosa, A., Llanos, P., Orellana, P., Videla, L.A., Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues (2015) Prostaglandins, Leukotrienes, and Essential Fatty Acids, 98, pp. 7-14; Wang, S.Y., Jiao, H., Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen (2000) Journal of Agricultural and Food Chemistry, 48 (11), pp. 5677-5684; Yang, B., Chen, H.Q., Stanton, C., Ross, R.P., Zhang, H., Chen, Y.Q., Chen, W., Review of the roles of conjugated linoleic acid in health and disease (2015) Journal of Functional Foods, 15, pp. 314-325

PY - 2016

Y1 - 2016

N2 - Alzheimer's disease (AD) is the most common form of dementia. It is characterized by aggregation of amyloid plaques and neurofibrillary tangles. The neurotoxic action of amyloid β-peptide (Aβ) involves formation of reactive oxygen species. Trans fatty acids (TFAs) are not only exogenously derived from dietary food, but also endogenously formed by free radicals. Thus, we utilized the PC-12 cell model to investigate the correlation between radical stress and endogenous formed TFAs. The results showed that thiyl radicals significantly increased TFA formation in PC-12 cells in both pre-treatment and co-treatment experiments. It was also found that retinol acetate significantly decreased thiyl radical-catalysed TFA formation in PC-12 cells. The anti-isomerization activity of retinol acetate resulted, at least in part, from its high absorption efficiency by PC-12 cells and its thiyl radical scavenging activity. Therefore, retinol acetate may serve as a potential antioxidant for functional foods against TFA formation during pathogenesis of AD. © 2015 Elsevier Ltd.

AB - Alzheimer's disease (AD) is the most common form of dementia. It is characterized by aggregation of amyloid plaques and neurofibrillary tangles. The neurotoxic action of amyloid β-peptide (Aβ) involves formation of reactive oxygen species. Trans fatty acids (TFAs) are not only exogenously derived from dietary food, but also endogenously formed by free radicals. Thus, we utilized the PC-12 cell model to investigate the correlation between radical stress and endogenous formed TFAs. The results showed that thiyl radicals significantly increased TFA formation in PC-12 cells in both pre-treatment and co-treatment experiments. It was also found that retinol acetate significantly decreased thiyl radical-catalysed TFA formation in PC-12 cells. The anti-isomerization activity of retinol acetate resulted, at least in part, from its high absorption efficiency by PC-12 cells and its thiyl radical scavenging activity. Therefore, retinol acetate may serve as a potential antioxidant for functional foods against TFA formation during pathogenesis of AD. © 2015 Elsevier Ltd.

KW - Alzheimer's disease

KW - Retinol acetate

KW - Thiyl radicals

KW - Trans fatty acids

U2 - 10.1016/j.jff.2015.12.005

DO - 10.1016/j.jff.2015.12.005

M3 - Article

VL - 21

SP - 212

EP - 222

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -