Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells

Yuh Chi Kuo, Chung Kung Lu, Li Wei Huang, Yueh Hsiung Kuo, Chen Chang, Feng Lin Hsu, Zong-Huei Li

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.

Original languageEnglish
Pages (from-to)412-415
Number of pages4
JournalPlanta Medica
Volume71
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Cinnamomum
kaempferol
mononuclear leukocytes
Glycosides
glycosides
Blood Cells
Blood
phytohemagglutinin
Cell proliferation
Phytohemagglutinins
leaves
cell proliferation
Cell Proliferation
Spectroscopic analysis
interleukin-2
leaf extracts
Modulators
Inhibitory Concentration 50
Interleukin-2
inhibitory concentration 50

Keywords

  • Acylated kaempferol glycosides
  • Cinnamomum kotoense
  • Interleukin-2
  • Lauraceae
  • Leaves
  • PBMC proliferation

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. / Kuo, Yuh Chi; Lu, Chung Kung; Huang, Li Wei; Kuo, Yueh Hsiung; Chang, Chen; Hsu, Feng Lin; Li, Zong-Huei.

In: Planta Medica, Vol. 71, No. 5, 05.2005, p. 412-415.

Research output: Contribution to journalArticle

Kuo, Yuh Chi ; Lu, Chung Kung ; Huang, Li Wei ; Kuo, Yueh Hsiung ; Chang, Chen ; Hsu, Feng Lin ; Li, Zong-Huei. / Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. In: Planta Medica. 2005 ; Vol. 71, No. 5. pp. 412-415.
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