Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells

Yuh Chi Kuo, Chung Kung Lu, Li Wei Huang, Yueh Hsiung Kuo, Chen Chang, Feng Lin Hsu, Zong-Huei Li

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.

Original languageEnglish
Pages (from-to)412-415
Number of pages4
JournalPlanta Medica
Volume71
Issue number5
DOIs
Publication statusPublished - May 2005

Keywords

  • Acylated kaempferol glycosides
  • Cinnamomum kotoense
  • Interleukin-2
  • Lauraceae
  • Leaves
  • PBMC proliferation

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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