Abstract
A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
| Original language | English |
|---|---|
| Pages (from-to) | 412-415 |
| Number of pages | 4 |
| Journal | Planta Medica |
| Volume | 71 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2005 |
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Keywords
- Acylated kaempferol glycosides
- Cinnamomum kotoense
- Interleukin-2
- Lauraceae
- Leaves
- PBMC proliferation
ASJC Scopus subject areas
- Plant Science
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. / Kuo, Yuh Chi; Lu, Chung Kung; Huang, Li Wei; Kuo, Yueh Hsiung; Chang, Chen; Hsu, Feng Lin; Li, Zong-Huei.
In: Planta Medica, Vol. 71, No. 5, 05.2005, p. 412-415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells
AU - Kuo, Yuh Chi
AU - Lu, Chung Kung
AU - Huang, Li Wei
AU - Kuo, Yueh Hsiung
AU - Chang, Chen
AU - Hsu, Feng Lin
AU - Li, Zong-Huei
PY - 2005/5
Y1 - 2005/5
N2 - A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
AB - A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
KW - Acylated kaempferol glycosides
KW - Cinnamomum kotoense
KW - Interleukin-2
KW - Lauraceae
KW - Leaves
KW - PBMC proliferation
UR - http://www.scopus.com/inward/record.url?scp=20544434772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20544434772&partnerID=8YFLogxK
U2 - 10.1055/s-2005-864134
DO - 10.1055/s-2005-864134
M3 - Article
VL - 71
SP - 412
EP - 415
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 5
ER -