Abstract
A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
Original language | English |
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Pages (from-to) | 412-415 |
Number of pages | 4 |
Journal | Planta Medica |
Volume | 71 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2005 |
Keywords
- Acylated kaempferol glycosides
- Cinnamomum kotoense
- Interleukin-2
- Lauraceae
- Leaves
- PBMC proliferation
ASJC Scopus subject areas
- Plant Science
- Drug Discovery
- Organic Chemistry
- Pharmacology