Inhibitory effect of Magnolia Officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits

Weng Cheng Chang, Ya Mei Yu, Yuan Man Hsu, Chieh Hsi Wu, Pao Lun Yin, Su Yin Chiang, Jui Sung Hung

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Oxidative stress and apoptosis are 2 major characteristics of the progression of atherosclerosis. Both lovastatin and Magnolia officinalis are hypocholesterolemic agents. Therefore, we investigated the effect of M. officinalis extract on the prevention of atherosclerosis in comparison with lovastatin. Twenty hyperlipidemic rabbits were served one of the following diets: a high-fat and cholesterol diet (cholesterol group, 10% corn oil and 0.5% cholesterol), a high fat and cholesterol diet supplemented with M. officinalis extract (300 mg/kg) or lovastatin (6 mg/kg). The plasma lipids, oxidative stress (measured by free radical, malondialdehyde, and oxidative DNA damage), and arterial lesions significantly decreased in the M. officinalis and lovastatin groups when compared with the cholesterol group. Moreover, the expressions of Fas ligand, caspase 8, and caspase 9 in the aortic arches were also markedly lowered after M. officinalis and lovastatin supplements. Therefore, the results indicate that the antiatherogenic effect of M. officinalis is involved with a suppression of oxidative stress and with the down-regulation of apoptosis-related gene expression in hyperlipidemic rabbits.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 2006
Externally publishedYes

Keywords

  • Apoptosis
  • Hyperlipidemia
  • Lovastatin
  • Magnolia officinalis
  • Oxidative stress
  • Rabbit

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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