Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds

Shiow Yunn Sheu; Hsüch Ching Chiang

Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds

Shiow Yunn Sheu, Hsüch Ching Chiang

Research output: Contribution to journal › Article › peer-review

Abstract

Eighteen anthraquinones and related compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that anthrarobin and purpurin showed moderate effects on xanthine oxidase inhibition (IC₅₀ = 68.35 and 105.13 μM; Ki = 122.38 mid 130.49 μM respectively), and both of them induced mixed type (competitive-non-competitive) inhibition with respect to the substrate xanthine.

Original language	English
Pages (from-to)	3293-3297
Number of pages	5
Journal	Anticancer Research
Volume	17
Issue number	5 A
Publication status	Published - Sep 1997

Keywords

Anthracene (anthrarobin)
Anthraquinone (purpurin)
Antibacterial
Xanthine oxidase inhibitors

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds",

abstract = "Eighteen anthraquinones and related compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that anthrarobin and purpurin showed moderate effects on xanthine oxidase inhibition (IC50 = 68.35 and 105.13 μM; Ki = 122.38 mid 130.49 μM respectively), and both of them induced mixed type (competitive-non-competitive) inhibition with respect to the substrate xanthine.",

keywords = "Anthracene (anthrarobin), Anthraquinone (purpurin), Antibacterial, Xanthine oxidase inhibitors",

author = "Sheu, {Shiow Yunn} and Chiang, {Hs{\"u}ch Ching}",

year = "1997",

month = sep,

language = "English",

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journal = "Anticancer Research",

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T1 - Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds

AU - Sheu, Shiow Yunn

AU - Chiang, Hsüch Ching

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N2 - Eighteen anthraquinones and related compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that anthrarobin and purpurin showed moderate effects on xanthine oxidase inhibition (IC50 = 68.35 and 105.13 μM; Ki = 122.38 mid 130.49 μM respectively), and both of them induced mixed type (competitive-non-competitive) inhibition with respect to the substrate xanthine.

AB - Eighteen anthraquinones and related compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that anthrarobin and purpurin showed moderate effects on xanthine oxidase inhibition (IC50 = 68.35 and 105.13 μM; Ki = 122.38 mid 130.49 μM respectively), and both of them induced mixed type (competitive-non-competitive) inhibition with respect to the substrate xanthine.

KW - Anthracene (anthrarobin)

KW - Anthraquinone (purpurin)

KW - Antibacterial

KW - Xanthine oxidase inhibitors

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Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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