Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds

Shiow Yunn Sheu, Hsüch Ching Chiang

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Abstract

Eighteen anthraquinones and related compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that anthrarobin and purpurin showed moderate effects on xanthine oxidase inhibition (IC50 = 68.35 and 105.13 μM; Ki = 122.38 mid 130.49 μM respectively), and both of them induced mixed type (competitive-non-competitive) inhibition with respect to the substrate xanthine.

Original languageEnglish
Pages (from-to)3293-3297
Number of pages5
JournalAnticancer Research
Volume17
Issue number5 A
Publication statusPublished - Sep 1997

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Keywords

  • Anthracene (anthrarobin)
  • Anthraquinone (purpurin)
  • Antibacterial
  • Xanthine oxidase inhibitors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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