Inhibition of platelet thromboxane formation and phosphoinositides breakdown by diisoeugenol

C. H. Lin, Y. H. Kuo, Y. L. Lin, C. M. Teng

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diisoeugenol inhibited the platelet aggregation and ATP release of rabbit platelets caused by ADP, arachidonic acid, platelet-activating factor (PAF), collagen and thrombin. Prolongation of the incubation time of platelets with diisoeugenol did not cause further inhibition and the aggregability of platelets could not be restored after washing. In human platelet-rich plasma, diisoeugenol inhibited the biphasic aggregation and ATP release induced by adrenaline and ADP in a concentration-dependent manner. Thromboxane B2 formation caused by arachidonic acid, collagen and thrombin was markedly inhibited by diisoeugenol in a concentration-dependent manner. Diisoeugenol also inhibited the formation of inositol monophosphate caused by collagen, PAF and thrombin. The cAMP level of washed platelets was not changed by diisoeugenol. It is concluded that the antiplatelet effect of diisoeugenol is due to the inhibition of thromboxane formation and phosphoinositides breakdown.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume46
Issue number1
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Thromboxanes
Phosphatidylinositols
Blood Platelets
Thrombin
Collagen
Platelet Activating Factor
Arachidonic Acid
Adenosine Diphosphate
Adenosine Triphosphate
Thromboxane B2
Platelet-Rich Plasma
Inositol
diisoeugenol
Platelet Aggregation
Epinephrine
Rabbits

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Inhibition of platelet thromboxane formation and phosphoinositides breakdown by diisoeugenol. / Lin, C. H.; Kuo, Y. H.; Lin, Y. L.; Teng, C. M.

In: Journal of Pharmacy and Pharmacology, Vol. 46, No. 1, 1994, p. 54-57.

Research output: Contribution to journalArticle

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