Inhibition of platelet aggregation by some flavonoids

Shu Huey Tzeng, Wun Chang Ko, Feng Nien Ko, Che Ming Teng

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180 Citations (Scopus)

Abstract

The inhibitory effects of five flavonoids on the aggregation and secretion of platelets were studied. These flavonoids inhibited markedly platelet aggregation and ATP release of rabbit platelets induced by arachidonic acid or collagen, and slightly those by platelet-activating factor. ADP-induced platelet aggregation was also suppressed by myricetin, fisetin and quercetin. The IC50 on arachidonic acid-induced platelet aggregation was: fisetin, 22 μM; kaempferol, 20 μM; quercetin, 13 μM; morin, 150 μM502 formations were also inhibited by flavonoids in platelets challenged with arachidonic acid. Fisetin, kaempferol, morin and quercetin antagonized the aggregation of washed platelets induced by U46619, a thromboxane A2/prostaglandin endoperoxides mimetic receptor agonist. In human platelet-rich plasma, quercetin prevented the secondary aggregation and blocked ATP release from platelets induced by epinephrine or ADP. These results demonstrate that the major antiplatelet effect of flavonoids tested may be due to both the inhibition of thromboxane formation and thromboxane receptor antagonism.

Original languageEnglish
Pages (from-to)91-100
Number of pages10
JournalThrombosis Research
Volume64
Issue number1
DOIs
Publication statusPublished - Oct 1 1991

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Keywords

  • Flavonoids
  • Platelet inhibition
  • Thromboxane formation
  • Thromboxane receptor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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