Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate

Li Kwan Chang, Ta Tung Wei, Ya Fang Chiu, Chao Ping Tung, Jian Ying Chuang, Shang K. Hung, Ching Li, Shih Tung Liu

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

(-)-Epigallocatechin gallate (EGCG), abundant in green tea, is a potent anti-microbial and anti-tumor compound. This investigation used immunoblot, flow cytometry, microarray, and indirect immunofluorescence analyses to show that at concentrations exceeding 50μM, EGCG inhibits the expression of Epstein-Barr virus (EBV) lytic proteins, including Rta, Zta, and EA-D, but does not affect the expression of EBNA-1. Moreover, DNA microarray and transient transfection analyses demonstrated that EGCG blocks EBV lytic cycle by inhibiting the transcription of immediate-early genes, thus inhibiting the initiation of EBV lytic cascade.

Original languageEnglish
Pages (from-to)1062-1068
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume301
Issue number4
DOIs
Publication statusPublished - Feb 21 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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