Inhibition of cardiac hypertrophy effects in d-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment

Yung Ming Chang, Hen Hong Chang, Hung Jen Lin, Chin Chuan Tsai, Chuan Te Tsai, Hsin Nung Chang, Shu Luan Lin, Vijaya Padmaviswanadha, Ray Jade Chen, Chih Yang Huang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aging is a complex physiological phenomenon accelerated by ROS accumulation, with multisystem decline and increasing vulnerability to degenerative diseases and death. Cardiac hypertrophy is a key pathophysiological component that accompanies the aging process. Alpinate Oxyphyllae Fructus (Alpinia oxyphylla MIQ, AOF) is a traditional Chinese medicine, which provides cardioprotective activity against aging, hypertension, and cerebrovascular disorders. In this study, we found the protective effect of AOF against cardiac hypertrophy in D-galactose-induced aging rat model. The results showed that treating rats with D-galactose resulted in pathological hypertrophy as evident from the morphology change, increased left ventricular weight/whole heart weight, and expression of hypertrophy-related markers (MYH7 and BNP). Both concentric and eccentric cardiac hypertrophy signaling proteins were upregulated in aging rat model. However, these pathological changes were significantly improved in AOF treated group (AM and AH) in a dose-dependent manner. AOF negatively modulated D-galactose-induced cardiac hypertrophy signaling mechanism to attenuate ventricular hypertrophy. These enhanced cardioprotective activities following oral administration of AOF reflect the potential use of AOF for antiaging treatments.

Original languageEnglish
Article number2624384
JournalEvidence-based Complementary and Alternative Medicine
Volume2017
DOIs
Publication statusPublished - 2017

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Cardiomegaly
Galactose
Hypertrophy
Alpinia
Physiological Phenomena
Cerebrovascular Disorders
Weights and Measures
Chinese Traditional Medicine
Therapeutics
Oral Administration
Hypertension
Proteins

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Inhibition of cardiac hypertrophy effects in d-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment. / Chang, Yung Ming; Chang, Hen Hong; Lin, Hung Jen; Tsai, Chin Chuan; Tsai, Chuan Te; Chang, Hsin Nung; Lin, Shu Luan; Padmaviswanadha, Vijaya; Chen, Ray Jade; Huang, Chih Yang.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2017, 2624384, 2017.

Research output: Contribution to journalArticle

Chang, Yung Ming ; Chang, Hen Hong ; Lin, Hung Jen ; Tsai, Chin Chuan ; Tsai, Chuan Te ; Chang, Hsin Nung ; Lin, Shu Luan ; Padmaviswanadha, Vijaya ; Chen, Ray Jade ; Huang, Chih Yang. / Inhibition of cardiac hypertrophy effects in d-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment. In: Evidence-based Complementary and Alternative Medicine. 2017 ; Vol. 2017.
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AU - Tsai, Chuan Te

AU - Chang, Hsin Nung

AU - Lin, Shu Luan

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AU - Chen, Ray Jade

AU - Huang, Chih Yang

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