Inhibition of aqueous extracts of Solanum nigrum (AESN) on oral cancer through regulation of mitochondrial fission

Wu Ching Uen, Bao Hong Lee, Yeu Ching Shi, She Ching Wu, Chen Jei Tai, Cheng Jeng Tai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study is designed to investigate the anti-oral cancer properties of Solanum nigrum on oral squamous cell carcinoma. S. nigrum is a Chinese herb used for suppression of various cancers. However, the inhibition of S nigrum on oral cancer is unclear. Therefore, human oral squamous cancer cells (SCC)-4 were used to evaluate the effect of aqueous extracts of S nigrum (AESN) on cancer cell proliferation, cell cycle, mitochondrial function and apoptosis. The SCC-4 cells were treated by AESN to evaluate the inhibition of cell proliferation and mitochondrial function in vitro. Our results suggested that AESN markedly increased reactive oxygen species production. AESN also promoted caspase-9 and caspase-3 activation and subsequent triggering of the mitochondrial apoptotic pathway. The inhibition of glucose uptake was alleviated mediated by a dose-dependent manner in SCC-4 cells with AESN treatment for 24 h, resulting in mitochondrial fission. These results suggested that AESN has potential to be used as a functional food in adjuvant chemotherapy for treating human oral cancer by suppression of mitochondrial function.

Original languageEnglish
JournalJournal of Traditional and Complementary Medicine
DOIs
Publication statusPublished - 2018

Keywords

  • Apoptosis
  • Mitochondrial fission
  • Mitochondrial function
  • Oral squamous cell carcinoma
  • Solanum nigrum

ASJC Scopus subject areas

  • Complementary and alternative medicine

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