Inherited protein C deficiency with acute ischemic stroke in a young adult

A case report

Fu Chi Yang, Chang Hung Hsu, Jiann Chyun Lin, Cheng Yu Chen, Jiunn Tay Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hereditary protein C deficiency is inherited primarily as an autosomal dominant trait with incomplete penetrance. Arterial thrombosis, especially of the intracranial arteries, due to this deficiency is relatively rare. A 31-year-old man was admitted to our department because of sudden onset of neurological symptoms. Magnetic resonance imaging of the brain disclosed an acute ischemic infarction of the area supplied by the left middle cerebral artery. Protein C antigen was 40.7% (77-129%) and protein C activity was 46.3% (70-140%). No other possible associated causes of stroke were present. A survey of his relatives for protein C deficiency showed this deficiency in his mother, brother, sister and nephews. Protein C concentrations should be determined in cases of ischemic stroke in all young patients with no other major risk factors. Once protein C deficiency is detected, a search for protein C deficiency in the patient?s relatives should be performed to prevent the occurrence of ischemic strokes.

Original languageEnglish
Pages (from-to)601-604
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Volume19
Issue number6
DOIs
Publication statusPublished - Sep 2008
Externally publishedYes

Fingerprint

Protein C Deficiency
Young Adult
Protein C
Stroke
Siblings
Intracranial Thrombosis
Penetrance
Middle Cerebral Artery
Infarction
Arteries
Mothers
Magnetic Resonance Imaging
Antigens
Brain

Keywords

  • Cerebral ischemia
  • Coagulation disorder
  • Protein C

ASJC Scopus subject areas

  • Hematology

Cite this

Inherited protein C deficiency with acute ischemic stroke in a young adult : A case report. / Yang, Fu Chi; Hsu, Chang Hung; Lin, Jiann Chyun; Chen, Cheng Yu; Lee, Jiunn Tay.

In: Blood Coagulation and Fibrinolysis, Vol. 19, No. 6, 09.2008, p. 601-604.

Research output: Contribution to journalArticle

Yang, Fu Chi ; Hsu, Chang Hung ; Lin, Jiann Chyun ; Chen, Cheng Yu ; Lee, Jiunn Tay. / Inherited protein C deficiency with acute ischemic stroke in a young adult : A case report. In: Blood Coagulation and Fibrinolysis. 2008 ; Vol. 19, No. 6. pp. 601-604.
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