Ingested inorganic arsenic and prevalence of diabetes mellitus

Mei Shwu Lai, Yu-Mei Hsueh, Chien Jen Chen, Mei Pyng Shyu, Shu Yuan Chen, T. L. Kuo, Meei Maan Wu, Tung-Yuan Tai

Research output: Contribution to journalArticle

267 Citations (Scopus)

Abstract

To examine the association between ingested inorganic arsenic and prevalence of diabetes mellitus, in 1988, the authors studied 891 adults residing in villages in southern Taiwan where arseniasis is hyperendemic. The status of diabetes mellitus was determined by an oral glucose tolerance test and a history of diabetes regularly treated with sulfonylurea or insulin. The cumulative arsenic exposure in parts per million-years was calculated from the detailed history of residential addresses and duration of drinking artesian well water obtained through standardized interviews based on a structured questionnaire and the arsenic concentration in well water. The body mass index was derived from body height and weight measured according to a standard protocol, while the physical activity at work was also obtained by questionnaire interviews. Residents in villages where the chronic arseniasis was hyperendemic had a twofold increase in age-and sex-adjusted prevalence of diabetes mellitus compared with residents in Taipei City and the Taiwan area. There was a dose-response relation between cumulative arsenic exposure and prevalence of diabetes mellitus. The relation remained significant after adjustment for age, sex, body mass index, and activity level at work by a multiple logistic regression analysis giving a multivariate-adjusted odds ratio of 6.61 and 10.05, respectively, for those who had a cumulative arsenic exposure of 0.1-15.0 and greater than 15.0 ppm-year compared with those who were unexposed. These results suggest the chronic arsenic exposure may induce diabetes mellitus in humans.

Original languageEnglish
Pages (from-to)484-492
Number of pages9
JournalAmerican Journal of Epidemiology
Volume139
Issue number5
Publication statusPublished - Mar 1 1994

Fingerprint

Arsenic
Diabetes Mellitus
Taiwan
Body Mass Index
Water Wells
Interviews
Body Height
Water
Glucose Tolerance Test
Drinking
Logistic Models
Odds Ratio
Body Weight
Regression Analysis
Insulin

Keywords

  • Arsenic
  • Diabetes mellitus
  • Water
  • Water pollutants

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Lai, M. S., Hsueh, Y-M., Chen, C. J., Shyu, M. P., Chen, S. Y., Kuo, T. L., ... Tai, T-Y. (1994). Ingested inorganic arsenic and prevalence of diabetes mellitus. American Journal of Epidemiology, 139(5), 484-492.

Ingested inorganic arsenic and prevalence of diabetes mellitus. / Lai, Mei Shwu; Hsueh, Yu-Mei; Chen, Chien Jen; Shyu, Mei Pyng; Chen, Shu Yuan; Kuo, T. L.; Wu, Meei Maan; Tai, Tung-Yuan.

In: American Journal of Epidemiology, Vol. 139, No. 5, 01.03.1994, p. 484-492.

Research output: Contribution to journalArticle

Lai, MS, Hsueh, Y-M, Chen, CJ, Shyu, MP, Chen, SY, Kuo, TL, Wu, MM & Tai, T-Y 1994, 'Ingested inorganic arsenic and prevalence of diabetes mellitus', American Journal of Epidemiology, vol. 139, no. 5, pp. 484-492.
Lai MS, Hsueh Y-M, Chen CJ, Shyu MP, Chen SY, Kuo TL et al. Ingested inorganic arsenic and prevalence of diabetes mellitus. American Journal of Epidemiology. 1994 Mar 1;139(5):484-492.
Lai, Mei Shwu ; Hsueh, Yu-Mei ; Chen, Chien Jen ; Shyu, Mei Pyng ; Chen, Shu Yuan ; Kuo, T. L. ; Wu, Meei Maan ; Tai, Tung-Yuan. / Ingested inorganic arsenic and prevalence of diabetes mellitus. In: American Journal of Epidemiology. 1994 ; Vol. 139, No. 5. pp. 484-492.
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