Infrequent co-existence of nitric oxide synthase and parvalbumin, calbindin and calretinin immunoreactivity in rat pontine neurons

N. J. Dun, S. L. Dun, L. L. Hwang, U. Förstermann

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Neurons in the laterodorsal tegmental nucleus (LDTg), ventrolateral dorsal tegmental nucleus (LDTgV), pedunculopontine tegmental nucleus (PPTg), lateral and medial parabrachial nuclei (LPB and MPB) were immunoreactive to brain nitric oxide synthase (NOS) or isoform I. Double-labeling experiments showed that very few NOS-containing neurons in the pons were immunoreactive to any of the three calcium-binding proteins: cabndin-D 28K (CB-IR), parvalbumin (PV IR) and calretinin (CR-IR). These findings extend our previous observation in the neocortex and suggest that a population of central NOS-containing neurons can be neurochemically characterized as CB/CR/PV deficient.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - May 26 1995
Externally publishedYes



  • Calbindin
  • Calcium-binding proteins
  • Calretinin
  • NADPH diaphorase, Parvalbumin, Pontine reticular formation
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Neuroscience(all)

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