Infrequent co-existence of nitric oxide synthase and parvalbumin, calbindin and calretinin immunoreactivity in rat pontine neurons

N. J. Dun; S. L. Dun; L. L. Hwang; U. Förstermann

doi:10.1016/0304-3940(95)11582-H

Infrequent co-existence of nitric oxide synthase and parvalbumin, calbindin and calretinin immunoreactivity in rat pontine neurons

N. J. Dun, S. L. Dun, L. L. Hwang, U. Förstermann

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Neurons in the laterodorsal tegmental nucleus (LDTg), ventrolateral dorsal tegmental nucleus (LDT_gV), pedunculopontine tegmental nucleus (PPTg), lateral and medial parabrachial nuclei (LPB and MPB) were immunoreactive to brain nitric oxide synthase (NOS) or isoform I. Double-labeling experiments showed that very few NOS-containing neurons in the pons were immunoreactive to any of the three calcium-binding proteins: cabndin-D 28K (CB-IR), parvalbumin (PV IR) and calretinin (CR-IR). These findings extend our previous observation in the neocortex and suggest that a population of central NOS-containing neurons can be neurochemically characterized as CB/CR/PV deficient.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Neuroscience Letters
Volume	191
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(95)11582-H
Publication status	Published - May 26 1995
Externally published	Yes

Keywords

Calbindin
Calcium-binding proteins
Calretinin
NADPH diaphorase, Parvalbumin, Pontine reticular formation
Nitric oxide synthase

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(95)11582-H

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@article{1340ffe3c1804bb7bffb9aa0e3377946,

title = "Infrequent co-existence of nitric oxide synthase and parvalbumin, calbindin and calretinin immunoreactivity in rat pontine neurons",

abstract = "Neurons in the laterodorsal tegmental nucleus (LDTg), ventrolateral dorsal tegmental nucleus (LDTgV), pedunculopontine tegmental nucleus (PPTg), lateral and medial parabrachial nuclei (LPB and MPB) were immunoreactive to brain nitric oxide synthase (NOS) or isoform I. Double-labeling experiments showed that very few NOS-containing neurons in the pons were immunoreactive to any of the three calcium-binding proteins: cabndin-D 28K (CB-IR), parvalbumin (PV IR) and calretinin (CR-IR). These findings extend our previous observation in the neocortex and suggest that a population of central NOS-containing neurons can be neurochemically characterized as CB/CR/PV deficient.",

keywords = "Calbindin, Calcium-binding proteins, Calretinin, NADPH diaphorase, Parvalbumin, Pontine reticular formation, Nitric oxide synthase",

author = "Dun, {N. J.} and Dun, {S. L.} and Hwang, {L. L.} and U. F{\"o}rstermann",

note = "Funding Information: This study was supported by NIH Grants NS 18710 and NS 24226 from the Department of Health and Human Services (NJD) and by DFG Grants Fo 144/3-1 and Fo144/4-I from the Deutsche Forschungsgemeinschaft",

year = "1995",

month = may,

day = "26",

doi = "10.1016/0304-3940(95)11582-H",

language = "English",

volume = "191",

pages = "165--168",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

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TY - JOUR

T1 - Infrequent co-existence of nitric oxide synthase and parvalbumin, calbindin and calretinin immunoreactivity in rat pontine neurons

AU - Dun, N. J.

AU - Dun, S. L.

AU - Hwang, L. L.

AU - Förstermann, U.

N1 - Funding Information: This study was supported by NIH Grants NS 18710 and NS 24226 from the Department of Health and Human Services (NJD) and by DFG Grants Fo 144/3-1 and Fo144/4-I from the Deutsche Forschungsgemeinschaft

PY - 1995/5/26

Y1 - 1995/5/26

N2 - Neurons in the laterodorsal tegmental nucleus (LDTg), ventrolateral dorsal tegmental nucleus (LDTgV), pedunculopontine tegmental nucleus (PPTg), lateral and medial parabrachial nuclei (LPB and MPB) were immunoreactive to brain nitric oxide synthase (NOS) or isoform I. Double-labeling experiments showed that very few NOS-containing neurons in the pons were immunoreactive to any of the three calcium-binding proteins: cabndin-D 28K (CB-IR), parvalbumin (PV IR) and calretinin (CR-IR). These findings extend our previous observation in the neocortex and suggest that a population of central NOS-containing neurons can be neurochemically characterized as CB/CR/PV deficient.

AB - Neurons in the laterodorsal tegmental nucleus (LDTg), ventrolateral dorsal tegmental nucleus (LDTgV), pedunculopontine tegmental nucleus (PPTg), lateral and medial parabrachial nuclei (LPB and MPB) were immunoreactive to brain nitric oxide synthase (NOS) or isoform I. Double-labeling experiments showed that very few NOS-containing neurons in the pons were immunoreactive to any of the three calcium-binding proteins: cabndin-D 28K (CB-IR), parvalbumin (PV IR) and calretinin (CR-IR). These findings extend our previous observation in the neocortex and suggest that a population of central NOS-containing neurons can be neurochemically characterized as CB/CR/PV deficient.

KW - Calbindin

KW - Calcium-binding proteins

KW - Calretinin

KW - NADPH diaphorase, Parvalbumin, Pontine reticular formation

KW - Nitric oxide synthase

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U2 - 10.1016/0304-3940(95)11582-H

DO - 10.1016/0304-3940(95)11582-H

M3 - Article

C2 - 7543992

AN - SCOPUS:0029004689

SN - 0304-3940

VL - 191

SP - 165

EP - 168

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Infrequent co-existence of nitric oxide synthase and parvalbumin, calbindin and calretinin immunoreactivity in rat pontine neurons

Abstract

Keywords

ASJC Scopus subject areas

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