Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus

Ryoko Ichikawa, Masao Daimon, Tetsuro Miyazaki, Takayuki Kawata, Sakiko Miyazaki, Masaki Maruyama, Shuo Ju Chiang, Hiromasa Suzuki, Chiharu Ito, Fumihiko Sato, Hirotaka Watada, Hiroyuki Daida

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: We hypothesized that clinical factors other than glycemic control may influence abnormal cardiac function in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the independent factors for abnormal cardiac function among clinical factors in T2DM.Methods: We studied 148 asymptomatic patients with T2DM without overt heart disease. Echocardiographic findings were compared between diabetic patients and 68 age-matched healthy subjects. Early (E) and late (A) diastolic mitral flow velocity and early diastolic mitral annular velocity (e') were measured for assessing left ventricular (LV) diastolic function. We evaluated insulin resistance, non-esterified fatty acid, high-sensitive CRP, estimated glomerular filtration rate, waist/hip ratio, abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and other clinical characteristics in addition to glycemic control. VAT and SAT were quantified by computed tomography.Results: In T2DM, E/A and e' were significantly lower, and E/e', left atrial volume and LV mass were significantly greater than in control subjects. In multivariate liner regression analysis, VAT was an independent determinant of left atrial volume (β =0.203, p=0.011), E/A (β =-0.208, p=0.002), e' (β =-0.354, p

Original languageEnglish
Article number38
JournalCardiovascular Diabetology
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 27 2013
Externally publishedYes

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Type 2 Diabetes Mellitus
Intra-Abdominal Fat
Subcutaneous Fat
Abdominal Fat
Waist-Hip Ratio
Glomerular Filtration Rate
Left Ventricular Function
Insulin Resistance
Heart Diseases
Healthy Volunteers
Fatty Acids
Tomography
Regression Analysis

Keywords

  • Cardiac function
  • Diabetes mellitus
  • Echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. / Ichikawa, Ryoko; Daimon, Masao; Miyazaki, Tetsuro; Kawata, Takayuki; Miyazaki, Sakiko; Maruyama, Masaki; Chiang, Shuo Ju; Suzuki, Hiromasa; Ito, Chiharu; Sato, Fumihiko; Watada, Hirotaka; Daida, Hiroyuki.

In: Cardiovascular Diabetology, Vol. 12, No. 1, 38, 27.02.2013.

Research output: Contribution to journalArticle

Ichikawa, R, Daimon, M, Miyazaki, T, Kawata, T, Miyazaki, S, Maruyama, M, Chiang, SJ, Suzuki, H, Ito, C, Sato, F, Watada, H & Daida, H 2013, 'Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus', Cardiovascular Diabetology, vol. 12, no. 1, 38. https://doi.org/10.1186/1475-2840-12-38
Ichikawa, Ryoko ; Daimon, Masao ; Miyazaki, Tetsuro ; Kawata, Takayuki ; Miyazaki, Sakiko ; Maruyama, Masaki ; Chiang, Shuo Ju ; Suzuki, Hiromasa ; Ito, Chiharu ; Sato, Fumihiko ; Watada, Hirotaka ; Daida, Hiroyuki. / Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. In: Cardiovascular Diabetology. 2013 ; Vol. 12, No. 1.
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