Influences of cardiac mechano-electrical feedback on action potential duration

J. C. Hsieh, Shih Ann Chen, Cheng Jeng Tai, John K J Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages142
Number of pages1
Volume1
ISBN (Print)0780356756
Publication statusPublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Hsieh, J. C., Chen, S. A., Tai, C. J., & Li, J. K. J. (1999). Influences of cardiac mechano-electrical feedback on action potential duration. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 142). IEEE.