Abstract
The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.
| Original language | English |
|---|---|
| Pages (from-to) | 63-69 |
| Number of pages | 7 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Lubrication
- Microcrystalline cellulose
- Wet granulation
ASJC Scopus subject areas
- Biotechnology
- Pharmaceutical Science
Cite this
Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin. / Wu, J. S.; Ho, H. O.; Sheu, M. T.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 51, No. 1, 2001, p. 63-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin
AU - Wu, J. S.
AU - Ho, H. O.
AU - Sheu, M. T.
PY - 2001
Y1 - 2001
N2 - The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.
AB - The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.
KW - Lubrication
KW - Microcrystalline cellulose
KW - Wet granulation
UR - http://www.scopus.com/inward/record.url?scp=0035158060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035158060&partnerID=8YFLogxK
U2 - 10.1016/S0939-6411(00)00137-5
DO - 10.1016/S0939-6411(00)00137-5
M3 - Article
C2 - 11154905
AN - SCOPUS:0035158060
VL - 51
SP - 63
EP - 69
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
IS - 1
ER -