Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin

J. S. Wu, H. O. Ho, M. T. Sheu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume51
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Lubrication
Cyclodextrins
Cellulose
Powders
Excipients
Particle Size
Tablets
microcrystalline cellulose
Water

Keywords

  • Lubrication
  • Microcrystalline cellulose
  • Wet granulation

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

Cite this

@article{bc33f8b127c24aefb8251224c65acc06,
title = "Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin",
abstract = "The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0{\%}). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.",
keywords = "Lubrication, Microcrystalline cellulose, Wet granulation",
author = "Wu, {J. S.} and Ho, {H. O.} and Sheu, {M. T.}",
year = "2001",
doi = "10.1016/S0939-6411(00)00137-5",
language = "English",
volume = "51",
pages = "63--69",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin

AU - Wu, J. S.

AU - Ho, H. O.

AU - Sheu, M. T.

PY - 2001

Y1 - 2001

N2 - The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.

AB - The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of codried product and Avicels decreased with increasing particle size. Nevertheless, the compactibility of the codried excipient after granulation was still better than the non-granulated Avicel PH 101 and 301. On the other hand, codried product and Avicels were sensitive to lubrication and resulted in decreasing compactibility and increasing disintegration. Because of the rounder shape of particles, the codried excipient was more sensitive to magnesium stearate and produced weaker tablets than did Avicels.

KW - Lubrication

KW - Microcrystalline cellulose

KW - Wet granulation

UR - http://www.scopus.com/inward/record.url?scp=0035158060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035158060&partnerID=8YFLogxK

U2 - 10.1016/S0939-6411(00)00137-5

DO - 10.1016/S0939-6411(00)00137-5

M3 - Article

C2 - 11154905

AN - SCOPUS:0035158060

VL - 51

SP - 63

EP - 69

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 1

ER -