Influence of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C

Tsung Jung Lin, Li Ying Liao, Shyr Yi Lin, Chih Lin Lin, Ting An Chang

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21 Citations (Scopus)

Abstract

Aim: To evaluate the association among hepatic fibrosis, serum iron indices, and hepatic iron stores in patients with Chronic Hepatitis C (CHC). Methods: Thirty-two CHC patients were included in our study. The histological degree of fibrosis and inflammation activity was assessed according to the Metavir system. The serum iron indices including ferritin, iron and transferrin saturation were measured. Hepatic iron deposition was graded by Perls' stain. Results: The CHC patients with severe hepatic fibrosis (n = 16) were significantly older than CHC patients with mild fibrosis (n = 16) (P = 0.024). The serum iron indices, increased serum iron store and positive hepatic iron stain were not significantly different between the two groups. In multivariate logistic regression analysis, the age at biopsy was an independent predictor of severe hepatic fibrosis (Odds ratio = 1.312; P = 0.035). The positive hepatic iron stain was significantly associated with the values of alanine aminotransferase (ALT) (P = 0.017), ferritin (P = 0.008), serum iron (P = 0.019) and transferrin saturation (P = 0.003). The ferritin level showed significant correlation with the value of ALT (r = 0.531; P = 0.003), iron (r = 0.467; P = 0.011) and transferrin saturation (r = 0.556; P = 0.002). Conclusion: Our findings suggest that the severity of hepatitis C virus (HCV)-related liver injury is associated with patient age at biopsy. Both serum iron indices and hepatic iron deposition show correlation with serum indices of chronic liver disease but are not related to grade and stage of liver histology.

Original languageEnglish
Pages (from-to)4897-4901
Number of pages5
JournalWorld Journal of Gastroenterology
Volume12
Issue number30
Publication statusPublished - Aug 14 2006

Keywords

  • Chronic hepatitis C
  • Hepatic fibrosis
  • Hepatic iron
  • Hepatitis C virus
  • Serum iron

ASJC Scopus subject areas

  • Gastroenterology

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