Influence of Helicobacter pylori on gastric secretion and gastrin release in normal Chinese subjects

Guan Ying Tseng, Hwai Jeng Lin, Hsiao Yi Lin, Chin Lin Perng, Fa Yauh Lee, Wen Ching Lo, Shyh Haw Tsay, Anna Fen Yau Li, Full Young Chang, Shou Dong Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. Controversy exists concerning the influence of Helicobacter pylori on gastric secretion. Hyper-, normo- and hyposecretion of gastric acid in normal subjects with H pylori infection have been reported, although there is no such report for Chinese subjects. The goal of this study was to identify the effect of H pylori on gastric secretion in normal Chinese subjects. Methods. Twenty normal subjects with a normal upper gastrointestinal tract by endoscopy were recruited. H pylori status was assayed by a rapid urease test. Gastric secretion and gastrin release were also measured. Results. Among the subjects studied, nine were infected with H pylori. All enrolled subjects were males. Age and body weight were similar between both groups. No significant difference was found in basal acid output, maximal acid output, basal pepsin output or maximal pepsin output between the H pylori-positive group (median, 1.1 mmol/hour, 95% confidence interval 0.2-3.6 mmol/hour; 8.0, 3.0-18.3 mmol/hour; 0, -1.3-11.2 mmol/hour; and 4.1, -4.2-59.3 mmol/hour, respectively) and the H pylori-negative group (2.5, -1.3-11.3 mmol/hour; 12.2, 8.7-26.9 mmol/hour; 4.3, 1.8-13.5 mmol/hour; and 14.8, -5.7-73.0 mmol/hour, respectively). Serum basal gastrin and pepsinogen I concentration were 63.5, 50.0-78.6 pg/ml and 75.1, 50.6-89.8 ng/ml in the H pylori-positive group, and 65.9,50.2-79.8 pg/ml and 79.1, 59.5-120.1 ng/ml in the H pylori-negative group (p > 0.05). Conclusions. H pylori plays no role in the gastric secretion and gastrin release in normal Chinese subjects.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalChinese Medical Journal (Taipei)
Volume62
Issue number4
Publication statusPublished - Apr 1999
Externally publishedYes

Fingerprint

Pylorus
Gastrins
Helicobacter pylori
Stomach
Pepsin A
Pepsinogen A
Upper Gastrointestinal Tract
Acids
Gastrointestinal Endoscopy
Urease
Gastric Acid
Body Weight
Confidence Intervals
Infection

Keywords

  • Basal acid output
  • Gastrin
  • Helicobacter pylori
  • Maximal acid output
  • Pepsinogen I

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tseng, G. Y., Lin, H. J., Lin, H. Y., Perng, C. L., Lee, F. Y., Lo, W. C., ... Lee, S. D. (1999). Influence of Helicobacter pylori on gastric secretion and gastrin release in normal Chinese subjects. Chinese Medical Journal (Taipei), 62(4), 217-222.

Influence of Helicobacter pylori on gastric secretion and gastrin release in normal Chinese subjects. / Tseng, Guan Ying; Lin, Hwai Jeng; Lin, Hsiao Yi; Perng, Chin Lin; Lee, Fa Yauh; Lo, Wen Ching; Tsay, Shyh Haw; Li, Anna Fen Yau; Chang, Full Young; Lee, Shou Dong.

In: Chinese Medical Journal (Taipei), Vol. 62, No. 4, 04.1999, p. 217-222.

Research output: Contribution to journalArticle

Tseng, GY, Lin, HJ, Lin, HY, Perng, CL, Lee, FY, Lo, WC, Tsay, SH, Li, AFY, Chang, FY & Lee, SD 1999, 'Influence of Helicobacter pylori on gastric secretion and gastrin release in normal Chinese subjects', Chinese Medical Journal (Taipei), vol. 62, no. 4, pp. 217-222.
Tseng, Guan Ying ; Lin, Hwai Jeng ; Lin, Hsiao Yi ; Perng, Chin Lin ; Lee, Fa Yauh ; Lo, Wen Ching ; Tsay, Shyh Haw ; Li, Anna Fen Yau ; Chang, Full Young ; Lee, Shou Dong. / Influence of Helicobacter pylori on gastric secretion and gastrin release in normal Chinese subjects. In: Chinese Medical Journal (Taipei). 1999 ; Vol. 62, No. 4. pp. 217-222.
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abstract = "Background. Controversy exists concerning the influence of Helicobacter pylori on gastric secretion. Hyper-, normo- and hyposecretion of gastric acid in normal subjects with H pylori infection have been reported, although there is no such report for Chinese subjects. The goal of this study was to identify the effect of H pylori on gastric secretion in normal Chinese subjects. Methods. Twenty normal subjects with a normal upper gastrointestinal tract by endoscopy were recruited. H pylori status was assayed by a rapid urease test. Gastric secretion and gastrin release were also measured. Results. Among the subjects studied, nine were infected with H pylori. All enrolled subjects were males. Age and body weight were similar between both groups. No significant difference was found in basal acid output, maximal acid output, basal pepsin output or maximal pepsin output between the H pylori-positive group (median, 1.1 mmol/hour, 95{\%} confidence interval 0.2-3.6 mmol/hour; 8.0, 3.0-18.3 mmol/hour; 0, -1.3-11.2 mmol/hour; and 4.1, -4.2-59.3 mmol/hour, respectively) and the H pylori-negative group (2.5, -1.3-11.3 mmol/hour; 12.2, 8.7-26.9 mmol/hour; 4.3, 1.8-13.5 mmol/hour; and 14.8, -5.7-73.0 mmol/hour, respectively). Serum basal gastrin and pepsinogen I concentration were 63.5, 50.0-78.6 pg/ml and 75.1, 50.6-89.8 ng/ml in the H pylori-positive group, and 65.9,50.2-79.8 pg/ml and 79.1, 59.5-120.1 ng/ml in the H pylori-negative group (p > 0.05). Conclusions. H pylori plays no role in the gastric secretion and gastrin release in normal Chinese subjects.",
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AU - Lin, Hsiao Yi

AU - Perng, Chin Lin

AU - Lee, Fa Yauh

AU - Lo, Wen Ching

AU - Tsay, Shyh Haw

AU - Li, Anna Fen Yau

AU - Chang, Full Young

AU - Lee, Shou Dong

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N2 - Background. Controversy exists concerning the influence of Helicobacter pylori on gastric secretion. Hyper-, normo- and hyposecretion of gastric acid in normal subjects with H pylori infection have been reported, although there is no such report for Chinese subjects. The goal of this study was to identify the effect of H pylori on gastric secretion in normal Chinese subjects. Methods. Twenty normal subjects with a normal upper gastrointestinal tract by endoscopy were recruited. H pylori status was assayed by a rapid urease test. Gastric secretion and gastrin release were also measured. Results. Among the subjects studied, nine were infected with H pylori. All enrolled subjects were males. Age and body weight were similar between both groups. No significant difference was found in basal acid output, maximal acid output, basal pepsin output or maximal pepsin output between the H pylori-positive group (median, 1.1 mmol/hour, 95% confidence interval 0.2-3.6 mmol/hour; 8.0, 3.0-18.3 mmol/hour; 0, -1.3-11.2 mmol/hour; and 4.1, -4.2-59.3 mmol/hour, respectively) and the H pylori-negative group (2.5, -1.3-11.3 mmol/hour; 12.2, 8.7-26.9 mmol/hour; 4.3, 1.8-13.5 mmol/hour; and 14.8, -5.7-73.0 mmol/hour, respectively). Serum basal gastrin and pepsinogen I concentration were 63.5, 50.0-78.6 pg/ml and 75.1, 50.6-89.8 ng/ml in the H pylori-positive group, and 65.9,50.2-79.8 pg/ml and 79.1, 59.5-120.1 ng/ml in the H pylori-negative group (p > 0.05). Conclusions. H pylori plays no role in the gastric secretion and gastrin release in normal Chinese subjects.

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