Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan

Chia Chun Kao, M. U Kuan Chen, W. U Hsien Kuo, Tzy Yen Chen, Shih Chi Su, Y. I Hsien Hsieh, Chuen Lan Liu, Ming Chih Chou, Hsiu Ting Tsai, Shun F A Yang

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5 Citations (Scopus)

Abstract

Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalJournal of Surgical Oncology
Volume102
Issue number4
DOIs
Publication statusPublished - Sep 15 2010
Externally publishedYes

Keywords

  • Glutathione-S-transferases
  • Hepatocellular carcinoma
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Kao, C. C., Chen, M. U. K., Kuo, W. U. H., Chen, T. Y., Su, S. C., Hsieh, Y. I. H., Liu, C. L., Chou, M. C., Tsai, H. T., & Yang, S. F. A. (2010). Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan. Journal of Surgical Oncology, 102(4), 301-307. https://doi.org/10.1002/jso.21643