Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan

Chia Chun Kao, M. U Kuan Chen, W. U Hsien Kuo, Tzy Yen Chen, Shih Chi Su, Y. I Hsien Hsieh, Chuen Lan Liu, Ming Chih Chou, Hsiu Ting Tsai, Shun F A Yang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalJournal of Surgical Oncology
Volume102
Issue number4
DOIs
Publication statusPublished - Sep 15 2010
Externally publishedYes

Fingerprint

Taiwan
Hepatocellular Carcinoma
Genes
Neoplasm Genes
Xenobiotics
Genetic Polymorphisms
glutathione S-transferase T1
Cause of Death
Neoplasms
Biomarkers
Polymerase Chain Reaction
Liver
Serum

Keywords

  • Glutathione-S-transferases
  • Hepatocellular carcinoma
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan. / Kao, Chia Chun; Chen, M. U Kuan; Kuo, W. U Hsien; Chen, Tzy Yen; Su, Shih Chi; Hsieh, Y. I Hsien; Liu, Chuen Lan; Chou, Ming Chih; Tsai, Hsiu Ting; Yang, Shun F A.

In: Journal of Surgical Oncology, Vol. 102, No. 4, 15.09.2010, p. 301-307.

Research output: Contribution to journalArticle

Kao, Chia Chun ; Chen, M. U Kuan ; Kuo, W. U Hsien ; Chen, Tzy Yen ; Su, Shih Chi ; Hsieh, Y. I Hsien ; Liu, Chuen Lan ; Chou, Ming Chih ; Tsai, Hsiu Ting ; Yang, Shun F A. / Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan. In: Journal of Surgical Oncology. 2010 ; Vol. 102, No. 4. pp. 301-307.
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