Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass

Huey Ling Liou, Chun Che Shih, Yann Fen C. Chao, Nien Tsung Lin, Shau Ting Lai, Shu Hua Wang, Hsing I. Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cardiac surgery with cardiopulmonary bypass (CPB) induces a systemic inflammatory response syndrome that may contribute to postoperative morbidity and mortality. We investigated the inflammatory responses to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass. Thirty patients undergoing coronary artery bypass grafting (CABG) preparing for CPB were randomized into Ringer's solution (RS), 10% hydroxyethyl starch (HES) or 25% human albumin (HA) group. Serum concentrations of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured before CPB, at the end of CPB and 1, 6 and 12 h after CPB. Serum C-reactive protein (CRP) was determined pre-operatively and then daily for 2 days. Body-weight gain was significantly decreased on the day after surgery in the HES group than in the RS group. Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-α, IL-1β, IL-6 and higher levels of IL-10 compared to patients treated with RS. HES prime had lower levels of circulating CRP than in patients treated with HA or Ringer prime on the second post-operative day. Our data indicate that volume priming using colloid during CPB in CABG patients might exert beneficial effects on inflammatory responses.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalChinese Journal of Physiology
Volume55
Issue number3
DOIs
Publication statusPublished - Jan 1 2012
Externally publishedYes

Fingerprint

Colloids
Cardiopulmonary Bypass
Thoracic Surgery
Starch
Coronary Artery Bypass
Albumins
Interleukin-1
Interleukin-10
C-Reactive Protein
Interleukin-6
Tumor Necrosis Factor-alpha
Systemic Inflammatory Response Syndrome
crystalloid solutions
Ambulatory Surgical Procedures
Weight Gain
Blood Proteins
Body Weight
Morbidity
Mortality
Serum

Keywords

  • Cardiac surgery
  • Cardiopulmonary bypass
  • Inflammatory response
  • Priming solutions

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass. / Liou, Huey Ling; Shih, Chun Che; Chao, Yann Fen C.; Lin, Nien Tsung; Lai, Shau Ting; Wang, Shu Hua; Chen, Hsing I.

In: Chinese Journal of Physiology, Vol. 55, No. 3, 01.01.2012, p. 1-9.

Research output: Contribution to journalArticle

Liou, Huey Ling ; Shih, Chun Che ; Chao, Yann Fen C. ; Lin, Nien Tsung ; Lai, Shau Ting ; Wang, Shu Hua ; Chen, Hsing I. / Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass. In: Chinese Journal of Physiology. 2012 ; Vol. 55, No. 3. pp. 1-9.
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