Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

Ho Chang Kuo, Ya Ling Yang, Jiin Haur Chuang, Mao Meng Tiao, Hong Ren Yu, Li Tung Huang, Kuender D. Yang, Wei Chiao Chang, Chiu Ping Lee, Ying Hsien Huang

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24 Citations (Scopus)

Abstract

Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

Original languageEnglish
Pages (from-to)746-752
Number of pages7
JournalJournal of Clinical Immunology
Volume32
Issue number4
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

Keywords

  • Coronary artery lesion
  • Hemoglobin
  • Hepcidin
  • IL-6
  • Iron
  • Kawasaki disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Kuo, H. C., Yang, Y. L., Chuang, J. H., Tiao, M. M., Yu, H. R., Huang, L. T., Yang, K. D., Chang, W. C., Lee, C. P., & Huang, Y. H. (2012). Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease. Journal of Clinical Immunology, 32(4), 746-752. https://doi.org/10.1007/s10875-012-9668-1