Infectivity and pathogenicity of 14-month-cultured embryonated eggs of Toxocara canis in mice

Chia Kwung Fan, Yun Ho Lin, Wen Yuan Du, Kua Eyre Su

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37 Citations (Scopus)

Abstract

Infectivity and pathogenicity to mice of embryonated eggs of Toxocara canis, that had been maintained in 2% formalin for 14 months at 4°C, were evaluated by immunological and pathological assessment at 1, 4, 8, 12, 16, 20, 24, 28, 42 and 67 weeks post-infection (WPI). On each date, three infected mice and two age-matched uninfected mice were sacrificed for serum collection and histological processing of the liver, lungs, musculature, and brain. Infectivity assessment by enzyme-linked immunosorbent assay (ELISA) revealed that the overall immunological pattern of infected mice tended to be towards the Th2 type response. Serum IgG1 antibody titers in infected mice were significantly higher than that of the uninfected control mice throughout the trial (P

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalVeterinary Parasitology
Volume113
Issue number2
DOIs
Publication statusPublished - Apr 18 2003

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Keywords

  • Embryonated eggs
  • Infectivity
  • Mouse
  • Pathogenicity
  • Toxocara canis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Parasitology
  • veterinary(all)

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