Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study

Kuender D. Yang, Chia Yu Ou, Jen Chieh Chang, Rong Fu Chen, Chieh An Liu, Hsiu Mei Liang, Te Yao Hsu, Li Chen Chen, Shau Ku Huang

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Wheezing episodes are common in young infants. However, the molecular mechanism of wheezing is unclear, and very few therapeutic regimens are effective. Objective: This study investigated the genetic and environmental factors predisposing to infant wheezing in a birth cohort study. Methods: A cohort of 1211 pregnant women was recruited for this study. Infant wheezing episodes during the first 18 months of life were correlated to parental atopic history, parental smoking, prematurity, CB IgE levels, and the sequence variant (G+38A) of the Clara cell protein 10 (CC10) gene encoding a secretary anti-inflammatory CC10 protein. Results: Nine hundred eighty-three infants completed umbilical cord blood collection, and 813 infants completed the 18-month postnatal follow-up. Twenty-two percent of the infants experienced at least 1 wheezing episode, and 6.6% of the infants experienced frequent wheezing (≥3 episodes). Multivariate logistic regression showed that male sex and the CC10 G+38A polymorphism, but not prematurity, CB IgE level, passive smoking, or parental atopy, were predictors of frequent wheezing. Further studies found that infant frequent wheezing was significantly associated with the CC10 +38AA genotype and lower plasma CC10 levels at 18 months of age (P = .046), and infants with acute wheezing episodes had significantly lower CC10 levels than those without (P = .023). No association of wheezing episodes with allergic sensitization was observed in this cohort population. Conclusion: Infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy. Clinical implications: Lower CC10 expression, but not allergy sensitization, is involved in the pathogenesis of infant frequent wheezing.

Original languageEnglish
Pages (from-to)842-848
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume120
Issue number4
DOIs
Publication statusPublished - Oct 1 2007
Externally publishedYes

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Respiratory Sounds
Hypersensitivity
Cohort Studies
Proteins
Immunoglobulin E
Tobacco Smoke Pollution
Plasma Cells
Fetal Blood
Causality
Pregnant Women
Anti-Inflammatory Agents
Logistic Models
Smoking
History
Genotype
Parturition

Keywords

  • asthma
  • Clara cell 10-kd protein
  • cord blood IgE
  • gender
  • polymorphism
  • Wheezing infants

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. / Yang, Kuender D.; Ou, Chia Yu; Chang, Jen Chieh; Chen, Rong Fu; Liu, Chieh An; Liang, Hsiu Mei; Hsu, Te Yao; Chen, Li Chen; Huang, Shau Ku.

In: Journal of Allergy and Clinical Immunology, Vol. 120, No. 4, 01.10.2007, p. 842-848.

Research output: Contribution to journalArticle

Yang, Kuender D. ; Ou, Chia Yu ; Chang, Jen Chieh ; Chen, Rong Fu ; Liu, Chieh An ; Liang, Hsiu Mei ; Hsu, Te Yao ; Chen, Li Chen ; Huang, Shau Ku. / Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. In: Journal of Allergy and Clinical Immunology. 2007 ; Vol. 120, No. 4. pp. 842-848.
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T1 - Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study

AU - Yang, Kuender D.

AU - Ou, Chia Yu

AU - Chang, Jen Chieh

AU - Chen, Rong Fu

AU - Liu, Chieh An

AU - Liang, Hsiu Mei

AU - Hsu, Te Yao

AU - Chen, Li Chen

AU - Huang, Shau Ku

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Background: Wheezing episodes are common in young infants. However, the molecular mechanism of wheezing is unclear, and very few therapeutic regimens are effective. Objective: This study investigated the genetic and environmental factors predisposing to infant wheezing in a birth cohort study. Methods: A cohort of 1211 pregnant women was recruited for this study. Infant wheezing episodes during the first 18 months of life were correlated to parental atopic history, parental smoking, prematurity, CB IgE levels, and the sequence variant (G+38A) of the Clara cell protein 10 (CC10) gene encoding a secretary anti-inflammatory CC10 protein. Results: Nine hundred eighty-three infants completed umbilical cord blood collection, and 813 infants completed the 18-month postnatal follow-up. Twenty-two percent of the infants experienced at least 1 wheezing episode, and 6.6% of the infants experienced frequent wheezing (≥3 episodes). Multivariate logistic regression showed that male sex and the CC10 G+38A polymorphism, but not prematurity, CB IgE level, passive smoking, or parental atopy, were predictors of frequent wheezing. Further studies found that infant frequent wheezing was significantly associated with the CC10 +38AA genotype and lower plasma CC10 levels at 18 months of age (P = .046), and infants with acute wheezing episodes had significantly lower CC10 levels than those without (P = .023). No association of wheezing episodes with allergic sensitization was observed in this cohort population. Conclusion: Infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy. Clinical implications: Lower CC10 expression, but not allergy sensitization, is involved in the pathogenesis of infant frequent wheezing.

AB - Background: Wheezing episodes are common in young infants. However, the molecular mechanism of wheezing is unclear, and very few therapeutic regimens are effective. Objective: This study investigated the genetic and environmental factors predisposing to infant wheezing in a birth cohort study. Methods: A cohort of 1211 pregnant women was recruited for this study. Infant wheezing episodes during the first 18 months of life were correlated to parental atopic history, parental smoking, prematurity, CB IgE levels, and the sequence variant (G+38A) of the Clara cell protein 10 (CC10) gene encoding a secretary anti-inflammatory CC10 protein. Results: Nine hundred eighty-three infants completed umbilical cord blood collection, and 813 infants completed the 18-month postnatal follow-up. Twenty-two percent of the infants experienced at least 1 wheezing episode, and 6.6% of the infants experienced frequent wheezing (≥3 episodes). Multivariate logistic regression showed that male sex and the CC10 G+38A polymorphism, but not prematurity, CB IgE level, passive smoking, or parental atopy, were predictors of frequent wheezing. Further studies found that infant frequent wheezing was significantly associated with the CC10 +38AA genotype and lower plasma CC10 levels at 18 months of age (P = .046), and infants with acute wheezing episodes had significantly lower CC10 levels than those without (P = .023). No association of wheezing episodes with allergic sensitization was observed in this cohort population. Conclusion: Infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy. Clinical implications: Lower CC10 expression, but not allergy sensitization, is involved in the pathogenesis of infant frequent wheezing.

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KW - Clara cell 10-kd protein

KW - cord blood IgE

KW - gender

KW - polymorphism

KW - Wheezing infants

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