Induction of differentiation in rat C6 glioma cells with saikosaponins

Yan J. Tsai, I. Ling Chen, Lin Y. Horng, Rong Tsun Wu

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The effects of saikosaponins (a, b1, b2, c, d), isolated from Bupleurum Radix, on the induction of differentiation in rat C6 glioma cells were studied. Saikosaponins a and d were shown to inhibit cell proliferation and alter cell morphology. In addition to cytostasis, the enzymatic activities of glutamine synthetase (GS) and 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNP) were also noticeably increased after treatment with saikosaponin a. Nevertheless, saikosaponin d only showed an increase of GS activity, no significant changes in CNP activity were found. These results suggest that saikosaponin a can induce the differentiation of C6 glioma cells into astrocytes and/or oligodendrocytes, but saikosaponin d can only induce the differentiation of C6 glioma cells into astrocytes.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalPhytotherapy Research
Volume16
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • C6 glioma cells
  • Differentiation induction
  • Saikosaponins

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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