Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

Yu Fang Kuang, Yue-Hwa Chen

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

Original languageEnglish
Pages (from-to)1711-1718
Number of pages8
JournalFood and Chemical Toxicology
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Apoptosis
  • Indole-3-carbinol
  • Isothiocyanate
  • Lung adenocarcinoma A549 cells
  • P21
  • P53

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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