Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Yuh Cherng Guo, Che Mai Chang, Wen Li Hsu, Siou Jin Chiu, Yao Ting Tsai, Yii Her Chou, Ming Feng Hou, Jaw Yan Wang, Mei Hsien Lee, Ke Li Tsai, Wei Chiao Chang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

Original languageEnglish
Pages (from-to)6584-6596
Number of pages13
JournalMolecules
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Cell migration
  • COX-2
  • EGF
  • Indomethacin

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

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