Find Research Outputs

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder

Lin, C. W., Lin, H. Y., Lo, Y. C., Chen, Y. J., Hsu, Y. C., Chen, Y. L., Tseng, W. Y. I. & Gau, S. S. F., Mar 2 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 90, p. 76-83 8 p.

Research output: Contribution to journalArticle

Neuropsychological Tests
Anisotropy
Cerebellum
Cognition
Reaction Time

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Androgens
Prostatic Neoplasms
Cyclooxygenase Inhibitors
Androgen Receptors

A novel injectable in situ forming gel based on carboxymethyl hexanoyl chitosan/hyaluronic acid polymer blending for sustained release of berberine

Lu, K. Y., Lin, Y. C., Lu, H. T., Ho, Y. C., Weng, S. C., Tsai, M. L. & Mi, F. L., Feb 15 2019, In : Carbohydrate Polymers. 206, p. 664-673 10 p.

Research output: Contribution to journalArticle

Berberine
Hyaluronic acid
Hyaluronic Acid
Chitosan
Polymers

Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling

Chen, J. H., T.H Wu, A., T.W Tzeng, D., Huang, C. C., Tzeng, Y. M. & Chao, T. Y., Jan 1 2019, In : Phytomedicine. 52, p. 70-78 9 p.

Research output: Contribution to journalArticle

Antrodia
Neoplastic Stem Cells
beta Catenin
Drug Resistance
Carcinogenesis
1 Citations

Determination of citrus juice coumarins, furanocoumarins and methoxylated flavones using solid phase extraction and HPLC with photodiode array and fluorescence detection

Li, G. J., Wu, H. J., Wang, Y., Hung, W. L. & Rouseff, R. L., Jan 15 2019, In : Food Chemistry. 271, p. 29-38 10 p.

Research output: Contribution to journalArticle

citrus juices
Flavones
Coumarins
psoralens
coumarins

Effect of carbon nanotubes on in vitro cellular responses for bioglass application

Lin, J. N., Yeh, C. Y., Pan, Y. N., Lin, M. C. & Fan, F. Y., Jan 15 2019, In : Materials Letters. 235, p. 141-143 3 p.

Research output: Contribution to journalArticle

Bioactive glass
Carbon Nanotubes
Carbon nanotubes
carbon nanotubes
Composite materials

Effects of Chinese herbal medicine therapy on survival and hepatic outcomes in patients with hepatitis C virus infection in Taiwan

Tsai, F. J., Cheng, C. F., Chen, C. J., Lin, C. Y., Wu, Y. F., Li, T. M., Chuang, P. H., Wu, Y. C., Lai, C. H., Liu, X., Tsang, H., Lin, T. H., Liao, C. C., Huang, S. M., Li, J. P., Lin, J. C., Lin, C. C., Liang, W. M. & Lin, Y. J., Apr 1 2019, In : Phytomedicine. 57, p. 30-38 9 p.

Research output: Contribution to journalArticle

Folic acid inhibits colorectal cancer cell migration

Ting, P. C., Lee, W. R., Huo, Y. N., Hsu, S. P. & Lee, W. S., Jan 1 2019, In : Journal of Nutritional Biochemistry. 63, p. 157-164 8 p.

Research output: Contribution to journalArticle

Folic Acid
Small Interfering RNA
Cell Movement
Colorectal Neoplasms
Cells
Fathers
Longitudinal Studies
Anxiety
Mothers
Quality of Life
Interleukin-2 Receptors
Bipolar Disorder
Hippocampus
Inflammation
Tumor Necrosis Factor Receptors

Isothermal titration calorimetry for characterization of recombinant proteins

Baranauskiene, L., Kuo, T. C., Chen, W. Y. & Matulis, D., Feb 1 2019, In : Current Opinion in Biotechnology. 55, p. 9-15 7 p.

Research output: Contribution to journalReview article

Recombinant proteins
Calorimetry
Titration
Recombinant Proteins
Drug Design
Bipolar Disorder
Lithium
Drug Therapy
Phosphatidylinositol 3-Kinase
Atrial Remodeling

Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms

Spalatro, A. V., Amianto, F., Huang, Z., D'Agata, F., Bergui, M., Abbate Daga, G., Fassino, S. & Northoff, G., Jan 1 2019, In : European Psychiatry. 55, p. 10-17 8 p.

Research output: Contribution to journalArticle

Appetite Depressants
Bulimia Nervosa
Anorexia Nervosa
Psychometrics
Feeding and Eating Disorders

Ovatodiolide suppresses nasopharyngeal cancer by targeting stem cell-like population, inducing apoptosis, inhibiting EMT and dysregulating JAK/STAT signaling pathway

Liu, S. C., Huang, C. M., Bamodu, O. A., Lin, C. S., Liu, B. L., Tzeng, Y. M., Tsai, J. T., Lee, W. H. & Chen, T. M., Mar 15 2019, In : Phytomedicine. 56, p. 269-278 10 p.

Research output: Contribution to journalArticle

Personality and professional drivers’ driving behavior

Linkov, V., Zaoral, A., Řezáč, P. & Pai, C. W., Jan 1 2019, In : Transportation Research Part F: Traffic Psychology and Behaviour. 60, p. 105-110 6 p.

Research output: Contribution to journalArticle

traffic behavior
Personality
personality
driver
Truck drivers

Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex

Kuo, C. J., Huang, C. C., Chou, S. Y., Lo, Y. C., Kao, T. J., Huang, N. K., Lin, C., Lin, H. C., Lin, H. C. & Lee, Y. C., Feb 15 2019, In : Phytomedicine. 54, p. 132-139 8 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Curcumin
Therapeutic Uses
Memory Disorders
Lipids

Prediction of atrial fibrillation recurrence before catheter ablation using an adaptive nonlinear and non-stationary surface ECG analysis

Cui, X., Chang, H. C., Lin, L. Y., Yu, C. C., Hsieh, W. H., Li, W., Peng, C. K., Lin, J-L. & Lo, M. T., Jan 15 2019, In : Physica A: Statistical Mechanics and its Applications. 514, p. 9-19 11 p.

Research output: Contribution to journalArticle

fibrillation
Atrial Fibrillation
Ablation
Recurrence
ablation

SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury

Liao, W. J., Lin, H., Cheng, C. F., Ka, S. M., Chen, A. & Yang, R. B., Feb 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 2, p. 329-338 10 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Reperfusion Injury
Kidney
Ischemia
Reperfusion
Lipolysis
Cyclic AMP-Dependent Protein Kinases
Adipocytes
AMP-Activated Protein Kinases
Lipase

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1beta
Chemokine CCL2

Using artificial neural network to predict functional recovery of patients treated by intravenous thrombolysis in acute ischemic stroke

Chiu, H. W., Huang, Y. T. & Cheng, C. A., Jan 1 2019, In : IFMBE Proceedings. 68, 1, p. 331-334 4 p.

Research output: Contribution to journalConference article

Neural networks
Recovery
Emergency rooms
Neurons
Medicine

Weight loss and metabolic improvements in obese patients undergoing gastric banding and gastric banded plication: A comparison

Wang, W., Fann, C. S. J., Yang, S. H., Chen, H. H. & Chen, C. Y., Jan 1 2019, In : Nutrition. 57, p. 290-299 10 p.

Research output: Contribution to journalArticle

Weight Loss
Stomach
Blood Pressure
Triglycerides
Body Mass Index
2018
1 Citations

(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray

Chou, D., Peng, H. Y., Lin, T. B., Lai, C. Y., Hsieh, M. C., Wen, Y. C., Lee, A. S., Wang, H. H., Yang, P. S., Chen, G. D. & Ho, Y. C., Sep 1 2018, In : Neuropharmacology. 139, p. 1-12 12 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Mesencephalon
Antidepressive Agents
Depression
AMPA Receptors
3 Citations

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
Dioscorea
Glucose Intolerance
dipeptides
Dipeptides
yams
2 Citations

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
1 Citations

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Oct 1 2018, In : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

Research output: Contribution to journalArticle

Sirtuin 1
Dental Pulp
AMP-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Stem Cells
1 Citations

2018 consensus of the Taiwan Society of Cardiology and the Diabetes Association of Republic of China (Taiwan) on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases

Chiang, C. E., Lin, S. Y., Lin, T. H., Wang, T. D., Yeh, H. I., Chen, J. F., Tsai, C. T., Hung, Y. J., Li, Y. H., Liu, P. Y., Chang, K. C., Wang, K. L., Chao, T. H., Shyu, K. G., Yang, W. S., Ueng, K. C., Chu, P. H., Yin, W. H., Wu, Y. W., Cheng, H. M. & 7 othersShin, S. J., Huang, C. N., Chuang, L. M., Lin, S. J., Yeh, S. J., Sheu, W. H. H. & Lin, J. L., Mar 1 2018, In : Journal of the Chinese Medical Association. 81, 3, p. 189-222 34 p.

Research output: Contribution to journalArticle

Cardiology
Taiwan
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Pharmacology
1 Citations

2018 Guidelines of the Taiwan Society of Cardiology, Taiwan Society of Emergency Medicine and Taiwan Society of Cardiovascular Interventions for the management of non ST-segment elevation acute coronary syndrome

The Writing Group of 2018 Taiwan Guidelines for the Management of Non ST-segment Elevation Acute Coronary Syndrome, Sep 1 2018, In : Journal of the Formosan Medical Association. 117, 9, p. 766-790 25 p.

Research output: Contribution to journalArticle

Emergency Medicine
Acute Coronary Syndrome
Cardiology
Taiwan
Guidelines

2-naphthol levels and allergic disorders in children

Lin, T-J., Guo, Y. L., Hsu, J. C. & Wang, I. J., Jul 9 2018, In : International Journal of Environmental Research and Public Health. 15, 7, 1449.

Research output: Contribution to journalArticle

Urine
Oxidative Stress
Polycyclic Aromatic Hydrocarbons
Biomarkers
High Pressure Liquid Chromatography
1 Citations

4-acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-miR-324 re-expression

Bamodu, O. A., Yang, C. K., Cheng, W. H., Tzeng, D. T. W., Kuo, K. T., Huang, C. C., Deng, L., Hsiao, M., Lee, W. H. & Yeh, C. T., Aug 10 2018, In : Cancers. 10, 8, 269.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Colorectal Neoplasms
oxaliplatin
Phenotype
Fluorouracil

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 othersShih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Pharmaceutical Preparations

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
1 Citations

A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma

Weng, J. R., Dokla, E. M. E., Bai, L. Y., Chen, C. S., Chiu, S. J. & Shieh, T. M., Jan 1 2018, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology.

Research output: Contribution to journalArticle

Enzyme Activators
AMP-Activated Protein Kinases
Autophagy
Squamous Cell Carcinoma
Protein Tyrosine Phosphatases

AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage

Fang, C. C., Wu, C. F., Liao, Y. J., Huang, S. F., Chen, M. & Chen, Y. M. A., Dec 1 2018, In : Scientific Reports. 8, 1, 13802.

Research output: Contribution to journalArticle

Glycine N-Methyltransferase
Dependovirus
Carbon Tetrachloride
Hepatocellular Carcinoma
Liver
2 Citations

A bacterial pioneer produces cellulase complexes that persist through community succession

Kolinko, S., Wu, Y. W., Tachea, F., Denzel, E., Hiras, J., Gabriel, R., Bäcker, N., Chan, L. J. G., Eichorst, S. A., Frey, D., Chen, Q., Azadi, P., Adams, P. D., Pray, T. R., Tanjore, D., Petzold, C. J., Gladden, J. M., Simmons, B. A. & Singer, S. W., Jan 1 2018, In : Nature Microbiology. 3, 1, p. 99-107 9 p.

Research output: Contribution to journalArticle

Cellulase
Glycoside Hydrolases
Cellulosomes
Microbial Consortia
Metagenomics
6 Citations

Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia

Martino, M., Magioncalda, P., Yu, H., Li, X., Wang, Q., Meng, Y., Deng, W., Li, Y., Li, M., Ma, X., Lane, T., Duncan, N. W., Northoff, G. & Li, T., 2018, In : Schizophrenia Bulletin.

Research output: Contribution to journalArticle

Substantia Nigra
Schizophrenia
Dopamine
Pharmaceutical Preparations
Thalamus

A Case of Behçet’s Disease with Pulmonary Artery Aneurysm and Deep Venous Thrombosis

Chiang, Y., Lai, H-Y. & Lan, G-Y., 2018, RSROC2018中華民國放射線醫學會.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Behcet Syndrome
Venous Thrombosis
Pulmonary Artery
Aneurysm
Thrombosis
Return to Work
Head and Neck Neoplasms
Survivors
Appointments and Schedules
Taiwan
2 Citations
Clinical Decision Support Systems
Medical Order Entry Systems
Physicians
Health Facilities
Drug-Related Side Effects and Adverse Reactions
1 Citations

A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer

Huang, E. Y., Chang, Y. J., Huang, S. P., Lin, V. C., Yu, C. C., Huang, C. Y., Yin, H. L., Chang, T. Y., Lu, T. L. & Bao, B. Y., Jul 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 7, p. 3661-3670 10 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Single Nucleotide Polymorphism
Recurrence
Survival
Glycosyltransferases
5 Citations

A comparison study of SiO2/nano metal oxide composite sphere for antibacterial application

Hou, Y. X., Abdullah, H., Kuo, D. H., Leu, S. J., Gultom, N. S. & Su, C. H., Jan 15 2018, In : Composites Part B: Engineering. 133, p. 166-176 11 p.

Research output: Contribution to journalArticle

Oxides
Metals
Composite materials
Nanoparticles
Light emitting diodes

A composite of exhaled LTB4, LXA4, FeNO, and FEV1 as an “asthma classification ratio” characterizes childhood asthma

Chen, L. C., Tseng, H. M., Kuo, M. L., Chiu, C. Y., Liao, S. L., Su, K. W., Tsai, M. H., Hua, M. C., Lai, S. H., Yao, T. C., Yeh, K. W., Wu, A. H., Huang, J. L. & Huang, S. K., Mar 1 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 3, p. 627-634 8 p.

Research output: Contribution to journalArticle

Leukotriene B4
Asthma
Eicosanoids
Leukotriene E4
Dinoprostone

A cross-disciplinary successful aging intervention and evaluation: Comparison of person-to-person and digital-assisted approaches

Hsu, H. C., Kuo, T., Lin, J. P., Hsu, W. C., Yu, C. W., Chen, Y. C., Xie, W. Z., Hsu, W. C., Hsu, Y. L. & Yu, M. T., May 4 2018, In : International Journal of Environmental Research and Public Health. 15, 5, 0913.

Research output: Contribution to journalArticle

Health
Aptitude
Family Relations
Psychological Adaptation
Disease Management

Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities

Lkhagva, B., Kao, Y. H., Lee, T. I., Lee, T. W., Cheng, W. L. & Chen, Y. J., May 1 2018, (Accepted/In press) In : Epigenetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cardiac Myocytes
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
Enzymes
2 Citations

Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Fibroblasts
Nicotine
Chemical activation
Cells
Oxidative stress
MAP Kinase Signaling System
Nicotinic Receptors
Spasm
p38 Mitogen-Activated Protein Kinases

Active Tumor-Targeted co-Delivery of Epigallocatechin Gallate and Doxorubicin in Nanoparticles for Combination Gastric Cancer Therapy

Mi, F. L., Wang, L. F., Chu, P. Y., Peng, S. L., Feng, C. L., Lai, Y. J., Li, J. N. & Lin, Y. H., Aug 13 2018, In : ACS Biomaterials Science and Engineering. 4, 8, p. 2847-2859 13 p.

Research output: Contribution to journalArticle

Tumors
Cells
Nanoparticles
Hyaluronic acid
Glycoproteins