Increasing humidity blocks continuous positive airflow-induced apnea responses in rats

Ching Ting Tan, Hung Huey Tsai, Ching Yin Ho

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to investigate the role of temperature and humidity in positive continuous pressure flow-induced apnea. Methods: Forty-two adult male Sprague-Dawley rats were used in a functionally isolated laryngeal animal model. In study 1, animals were challenged with laryngeal stimulation for 1 minute to detect the possibility of adaptation. In study 2, different airflow conditions (25°C dry-25°C dry, 25°C dry-25°C wet, 25°C dry-37°C dry and 25°C dry-37°C wet) were delivered to determine the role of temperature and humidity in the flow-induced apneic response of the larynx. The apneic index was calculated by prolonged expiratory time/baseline expiratory time. Results: Laryngeal dry room temperature air exposure induced an apneic response, and this response was reproducible and could be eliminated by humidification. In contrast, this apneic response could not be inhibited by increasing temperature alone. In addition, prolonged cold dry air stimulation did not evoke a tachyphylactic effect to normalize the breathing pattern. Conclusion: Laryngeal cold dry air stimulation triggered an apneic response, which could be eliminated by humidification but not by the heating of air. These results suggest that using continuous positive airway pressure (CPAP) with humidified air decreases CPAP-induced apnea.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalJournal of the Chinese Medical Association
Volume73
Issue number7
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Apnea
Humidity
Air
Temperature
Continuous Positive Airway Pressure
Larynx
Heating
Sprague Dawley Rats
Respiration
Animal Models
Pressure

Keywords

  • Constant air flow
  • Continuous positive airway pressure
  • Humidification
  • Obstructive sleep apnea
  • Respiratory reflex

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Increasing humidity blocks continuous positive airflow-induced apnea responses in rats. / Tan, Ching Ting; Tsai, Hung Huey; Ho, Ching Yin.

In: Journal of the Chinese Medical Association, Vol. 73, No. 7, 07.2010, p. 369-374.

Research output: Contribution to journalArticle

Tan, Ching Ting ; Tsai, Hung Huey ; Ho, Ching Yin. / Increasing humidity blocks continuous positive airflow-induced apnea responses in rats. In: Journal of the Chinese Medical Association. 2010 ; Vol. 73, No. 7. pp. 369-374.
@article{7444683e8c0242798eb32fff61a0f975,
title = "Increasing humidity blocks continuous positive airflow-induced apnea responses in rats",
abstract = "Background: The aim of this study was to investigate the role of temperature and humidity in positive continuous pressure flow-induced apnea. Methods: Forty-two adult male Sprague-Dawley rats were used in a functionally isolated laryngeal animal model. In study 1, animals were challenged with laryngeal stimulation for 1 minute to detect the possibility of adaptation. In study 2, different airflow conditions (25°C dry-25°C dry, 25°C dry-25°C wet, 25°C dry-37°C dry and 25°C dry-37°C wet) were delivered to determine the role of temperature and humidity in the flow-induced apneic response of the larynx. The apneic index was calculated by prolonged expiratory time/baseline expiratory time. Results: Laryngeal dry room temperature air exposure induced an apneic response, and this response was reproducible and could be eliminated by humidification. In contrast, this apneic response could not be inhibited by increasing temperature alone. In addition, prolonged cold dry air stimulation did not evoke a tachyphylactic effect to normalize the breathing pattern. Conclusion: Laryngeal cold dry air stimulation triggered an apneic response, which could be eliminated by humidification but not by the heating of air. These results suggest that using continuous positive airway pressure (CPAP) with humidified air decreases CPAP-induced apnea.",
keywords = "Constant air flow, Continuous positive airway pressure, Humidification, Obstructive sleep apnea, Respiratory reflex",
author = "Tan, {Ching Ting} and Tsai, {Hung Huey} and Ho, {Ching Yin}",
year = "2010",
month = "7",
doi = "10.1016/S1726-4901(10)70080-0",
language = "English",
volume = "73",
pages = "369--374",
journal = "Journal of the Chinese Medical Association",
issn = "1726-4901",
publisher = "Elsevier Taiwan LLC",
number = "7",

}

TY - JOUR

T1 - Increasing humidity blocks continuous positive airflow-induced apnea responses in rats

AU - Tan, Ching Ting

AU - Tsai, Hung Huey

AU - Ho, Ching Yin

PY - 2010/7

Y1 - 2010/7

N2 - Background: The aim of this study was to investigate the role of temperature and humidity in positive continuous pressure flow-induced apnea. Methods: Forty-two adult male Sprague-Dawley rats were used in a functionally isolated laryngeal animal model. In study 1, animals were challenged with laryngeal stimulation for 1 minute to detect the possibility of adaptation. In study 2, different airflow conditions (25°C dry-25°C dry, 25°C dry-25°C wet, 25°C dry-37°C dry and 25°C dry-37°C wet) were delivered to determine the role of temperature and humidity in the flow-induced apneic response of the larynx. The apneic index was calculated by prolonged expiratory time/baseline expiratory time. Results: Laryngeal dry room temperature air exposure induced an apneic response, and this response was reproducible and could be eliminated by humidification. In contrast, this apneic response could not be inhibited by increasing temperature alone. In addition, prolonged cold dry air stimulation did not evoke a tachyphylactic effect to normalize the breathing pattern. Conclusion: Laryngeal cold dry air stimulation triggered an apneic response, which could be eliminated by humidification but not by the heating of air. These results suggest that using continuous positive airway pressure (CPAP) with humidified air decreases CPAP-induced apnea.

AB - Background: The aim of this study was to investigate the role of temperature and humidity in positive continuous pressure flow-induced apnea. Methods: Forty-two adult male Sprague-Dawley rats were used in a functionally isolated laryngeal animal model. In study 1, animals were challenged with laryngeal stimulation for 1 minute to detect the possibility of adaptation. In study 2, different airflow conditions (25°C dry-25°C dry, 25°C dry-25°C wet, 25°C dry-37°C dry and 25°C dry-37°C wet) were delivered to determine the role of temperature and humidity in the flow-induced apneic response of the larynx. The apneic index was calculated by prolonged expiratory time/baseline expiratory time. Results: Laryngeal dry room temperature air exposure induced an apneic response, and this response was reproducible and could be eliminated by humidification. In contrast, this apneic response could not be inhibited by increasing temperature alone. In addition, prolonged cold dry air stimulation did not evoke a tachyphylactic effect to normalize the breathing pattern. Conclusion: Laryngeal cold dry air stimulation triggered an apneic response, which could be eliminated by humidification but not by the heating of air. These results suggest that using continuous positive airway pressure (CPAP) with humidified air decreases CPAP-induced apnea.

KW - Constant air flow

KW - Continuous positive airway pressure

KW - Humidification

KW - Obstructive sleep apnea

KW - Respiratory reflex

UR - http://www.scopus.com/inward/record.url?scp=77955235232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955235232&partnerID=8YFLogxK

U2 - 10.1016/S1726-4901(10)70080-0

DO - 10.1016/S1726-4901(10)70080-0

M3 - Article

C2 - 20688303

AN - SCOPUS:77955235232

VL - 73

SP - 369

EP - 374

JO - Journal of the Chinese Medical Association

JF - Journal of the Chinese Medical Association

SN - 1726-4901

IS - 7

ER -