Increasing expression of fascin in renal cell carcinoma associated with clinicopathological parameters of aggressiveness

J. S. Jin, C. P. Yu, G. H. Sun, Y. F. Lin, H. Chiang, T. K. Chao, W. C. Tsai, L. F. Sheu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aim: To determine whether higher expression of fascin, an actin-bundling protein associated with motility, in conventional renal cell carcinoma (RCC) is associated with more advanced stages of the disease. Methods: Immunohistochemical analysis of fascin expression was performed in tissue microarrays of 108 RCCs including 55 clear cell RCCs (CRCCs), 39 CRCCs with granular cell differentiation (GRCCs), 8 CRCCs with sarcomatoid differentiation (SRCCs) and 6 metastatic RCCs. Results: The expression of fascin was undetectable in normal renal tubules of all control cases. However, among the 108 RCC cases, fascin immunoreactivity was seen on the cell membrane and cytoplasm. The average immunostaining score for fascin was 128/400 in grade I, 170/400 in grade 11, 207/400 in grade III, and 323/400 in grade IV RCC. The average immunostaining score of fascin was 187/400 for stage T1, 205/400 for stage T2, 288/400 for stage T3, and 355/400 for stage T4 cases of RCCs. Higher fascin scores in RCC were significantly correlated with higher T and N stages and nuclear grade. In addition, the fascin scores in GRCC (368±19) and SRCC (263±21) were significantly higher than in CRCC (95±18). Conclusions: Our findings demonstrate for the first time that increased expression of fascin is associated with clinicopathological parameters of aggressiveness in patients with RCC. Fascin may novel biomarker for diagnosis and treatment of RCC.

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalHistology and Histopathology
Volume21
Issue number10-12
Publication statusPublished - Oct 2006
Externally publishedYes

Keywords

  • Clear cell type
  • Fascin
  • Granular cell differentiation
  • Renal cell carcinoma
  • Sarcomatoid differentiation

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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    Jin, J. S., Yu, C. P., Sun, G. H., Lin, Y. F., Chiang, H., Chao, T. K., Tsai, W. C., & Sheu, L. F. (2006). Increasing expression of fascin in renal cell carcinoma associated with clinicopathological parameters of aggressiveness. Histology and Histopathology, 21(10-12), 1287-1293.