Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

Cheng Hsun Chiu, Lin Hui Su, Yhu Chering Huang, Jui Chia Lai, Hsiu Ling Chen, Tsu Lan Wu, Tzou Yien Lin

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The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

Original languageEnglish
Pages (from-to)3404-3406
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number9
Publication statusPublished - Sep 2007
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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