Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

Cheng Hsun Chiu, Lin Hui Su, Yhu Chering Huang, Jui Chia Lai, Hsiu Ling Chen, Tsu Lan Wu, Tzou Yien Lin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

Original languageEnglish
Pages (from-to)3404-3406
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number9
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

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Penicillin-Binding Proteins
Ceftriaxone
Streptococcus pneumoniae
Taiwan
Penicillins
Peptidyl Transferases
Amino Acids
Serogroup

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan. / Chiu, Cheng Hsun; Su, Lin Hui; Huang, Yhu Chering; Lai, Jui Chia; Chen, Hsiu Ling; Wu, Tsu Lan; Lin, Tzou Yien.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 9, 09.2007, p. 3404-3406.

Research output: Contribution to journalArticle

Chiu, Cheng Hsun ; Su, Lin Hui ; Huang, Yhu Chering ; Lai, Jui Chia ; Chen, Hsiu Ling ; Wu, Tsu Lan ; Lin, Tzou Yien. / Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 9. pp. 3404-3406.
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